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The Birthday Paradox

In biomedical research, dealing with probabilities is part of the daily routine for many scientists, independently of their specific research area. Statistics and probability calculations are important during the design phase of experiments (e.g., for group size calculation and power estimations), as well as during the …

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A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review

Irreproducibility of preclinical biomedical research has gained recent attention. To improve the quality and transparency of scientific reporting, some journals introduced checklists requiring authors to complete at the time of manuscript submission. Whether a checklist enhances data and reporting quality of preclinical animal studies, however, has …

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Findings of a retrospective, controlled cohort study of the impact of a change in Nature journals’ editorial policy for life sciences research on the completeness of reporting study design and execution.

Poor replication of in vivo and in vitro biomedical studies has been reported and this can be linked in many cases to insufficient descriptions of the experimental and analytical details. Thus, the aim of this study by Malcolm Macleod and the NPQIP Collaborative group was to …

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