In: Case Study
Estimation vs Hypothesis-Testing
November 22, 2019As some of our readers may know, the PAASP team was involved in the “Negative results Award” project that took place…
Read MoreLicense to Kill – From Killer Experiments and Synthetic Lethality
August 12, 2019The Maternal Embryonic Leucine zipper Kinase (MELK) is an interesting enzyme:In 2005, MELK was first implicated in cancer by finding elevated…
Read MoreSomething is rotten in the state of antibody quality
March 11, 2019A team of researchers led by Eleftherios P. Diamandis at the University of Toronto set out to discover novel serological markers…
Read MoreThe SOD1 mouse – 10 years later
December 20, 2018It has been more than 10 years since two seminal papers by Ludolph et al (2007) and Scott et al (2008) have introduced recommendations for…
Read MoreReporting details – Differential induction of innate immune responses by LPS
November 17, 2018The importance of reporting small details and making well-informed decisions about which information to include for each experimental parameter/factor in scientific…
Read More“Andromeda and Orion of modern biomarker research”
September 10, 2018Amyloid beta (Aß) accumulation in the brain is regarded as one of the histopathological hallmarks of Alzheimer’s disease. However, Aß build-up…
Read MoreReproducibility Issues – The Ghosts of HeLa
July 9, 2018Listeria monocytogenes is an intracellular pathogen and the causative agent of the food-borne disease listeriosis. This disease primarily affects pregnant women,…
Read MoreHeads I win, tails you lose
June 6, 2018Preclinical in vivo scientists often have to deal with a very interesting situation: Imagine we design a study to demonstrate that…
Read MoreReplication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
June 6, 2018As part of the “Reproducibility Project: Cancer Biology”, a Registered Report (Repass et al., 2016) was published in 2016, that described…
Read MoreMake hay while the sun shines
January 23, 2018“When she arrived, I gave her a data set of a self-funded, failed study which had null results (it was a…
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