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Is N-Hacking ever OK?

It has been proposed repeatedly that adding samples based on results of initial experiments is a form of p-hacking (see e.g. new Instructions to Authors of journals of the Am Soc Exp Pharmacol Ther). While these recommendations were based on sound theoretical considerations, Pamela Rainagel from San Diego …

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Publishers’ Responsibilities in Promoting Data Quality and Reproducibility

Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved by publishers in six key areas: (1) understanding researchers’ problems and motivations; (2) raising awareness of issues and encouraging behavioural and cultural change; (3) improving …

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Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods.

The reproducibility crisis in science is a multifaceted problem involving practices and incentives, both in the laboratory and in publication.Using SciScore, an automated tool developed to review the methods sections of manuscripts for the presence of criteria associated with the NIH and other reporting guidelines (e.g. …

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New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology

To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin Michel, T.J. Murphy and Harvey Motulsky, has updated the Instructions to Authors (ItA) for ASPET’s primary research journals: Drug Metabolism and Disposition, Journal of Pharmacology and Experimental …

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