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How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Reproducibility in preclinical research may be low because of the high prevalence of biases and of suboptimal research practices (such as biased allocation of experimental groups, experimenter bias and lack of necessary controls, the use of uncharacterized materials, poor use of statistics, poor scientific training, etc.). …

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Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

Today, the probability of successfully publishing negative/null results in biomedical research is lower than that for positive results. For instance, negative results repeatedly remain in lab books or drawers, or are not being published because they are rejected by scientific journals. These seemingly positive results then …

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Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

As part of the Reproducibility Project: Cancer Biology, this report describes the attempt to replicate critical experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota” (Arthur et al., 2012). In agreement with the original study, the authors did not observe any changes on …

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