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To Have Practical Relevance, Scientific Claims Need to be Accurate

For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is important that scientific claims are as accurate as possible. However, there is increasing evidence questioning the robustness and accuracy of social and biomedical research outcomes. …

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A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

The ARRIVE guidelines are widely endorsed but compliance is limited. The IICARus Collaboration group sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines. In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March-June …

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The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials

The question of how quality of preclinical data is connected to patients in clinical trials is addressed in this article by Yarborough et al. This discussion is certainly overdue as the ethical implementations of doing tests in human subjects without adequate preclinical justification are not bearable …

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