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Promoting transparency in preclinical research: preregistration of animal study protocols on www.preclinicaltrials.eu

Smit NW1, Van der Naald M2,3, Wever KE4, Duncker DJ1,5, Chamuleau SAJ2,3,6   1Netherlands Heart Institute, The Netherlands 2University Medical Center Utrecht, The Netherlands 3Member of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes 4SYRCLE, Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands 5Erasmus Medical Center, The …

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Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

Scientific articles using cell lines, which are registered on the International Cell Line Authentication Committee (ICLAC) or the Cellosaurus database as ‘misidentified’ continue to be published. Often, the routinely use of short-tandem repeat profiling to test for contamination is not implemented as a standard procedure. Research …

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Why we need to report more than ’Data were Analyzed by t-tests or ANOVA’

In this article,Weissgerber et al. present findings suggesting that scientific publications are often lacking sufficient information about the statistical methods used, which are required by independent scientists to successfully replicate the published results. The authors evaluated the quality of reporting of statistical tests (such as t-tests and …

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The Costs of Reproducibility

Improving the reproducibility of (biomedical) research is of great concern, especially to early-career researchers (ECRs). In this viewpoint article, Russell A. Poldrack from Stanford University outlines the potential costs for ECRs in adopting practices to improve reproducibility. He discusses the ways in which ECRs can achieve …

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