The iRISE project (Improving Reproducibility in Science), launched in September 2023 and funded by the European Union for three years, takes an integrated approach to understanding, investigating, and guiding strategies to address irreproducibility in research. Rather than focusing on a single cause or solution, the consortium looks at different points in the research process and examines how they can be strengthened. 

One of the first outputs of iRISE is a glossary that defines key concepts such as reproducibility, replicability, and robustness as understood by this consortium. The goal is not to claim a final, universal definition, but to make it clear what is meant when these terms are used, and to stimulate discussion. iRISE acknowledges that many different definitions exist in the literature and in practice, and that it may not be realistic to expect one universally accepted terminology. What is essential, however, is that each group clearly defines its terms so that readers and stakeholders know what is meant. 

The project also investigates a range of interventions that could improve reproducibility. Two of these interventions focus on the level of peer review, for example by exploring how changes in review processes might influence the quality and transparency of research. Another work stream uses simulation approaches to test different research parameters, such as choices in statistical design and analysis, and how they affect the reliability of findings. 

A further key component, where the Guarantors of EQIPD are directly involved, is the evaluation of the EQIPD Quality System and its impact on research practice. In this context, the first research units have already successfully completed the certification process: Atuka Inc in Canada, the ARTH Infinity Core at the University of Ghent, the Stoller Clinical Analysis Research Facility (SCARF) at the University of Manchester and the Preclinical Studies Center (CEPC) at the Einstein Hospital Israelita in São Paulo. These certifications are important milestones for both iRISE and EQIPD, and they provide excellent examples of how structured quality systems can be implemented in real research environments.

For more information, please contact Björn.