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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

At the presentation of the ECNP Negative Data Award (see above), there was an interesting point made by one of the presenters – about the important role of large multi-national multi-lab collaboration projects for the scientific progress. More specifically, it was emphasized that initiatives such as …

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Reproducibility of preclinical animal research improves with heterogeneity of study samples

Pre-clinical animal research is typically based on single-laboratory studies conducted under highly standardized conditions. However, a new study published by Bernhard Voelkl, Lucile Vogt, Emily S. Sena and Hanno Würbel from the Universities of Bern and Edinburgh showed that such approach risks producing results that are …

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Development of an information sharing platform – Pharma shares unpublished results

F1000 Research has published an article entitled “In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis” co-authored by PAASP’s managing partner Anton Bespalov, together with colleagues from AbbVie, Servier, Pfizer and Alkermes. Independently of each other, …

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