Improving the reproducibility of (biomedical) research is of great concern, especially to early-career researchers (ECRs). In this viewpoint article, Russell A. Poldrack from Stanford University outlines the potential costs for ECRs in adopting practices to improve reproducibility. He discusses the ways in which ECRs can achieve their career goals while doing better science and highlights the need for established researchers to support them in these efforts. Poldrack also comments on the likely scenario that investing into higher data quality comes with a price and, for example, larger sample sizes and replication of each study means fewer studies, which means fewer papers on the ECR’s CV: “In my discussions with ECRs, I also try not to sugarcoat the fact that some of the remedies we advocate are likely to make them less competitive on the job market in the short term.”