In this article, Nancy Baker and colleagues introduce the Abstract Sifter, a Microsoft Excel based application that enhances existing search capabilities of PubMed. The Abstract Sifter assists researchers to search effectively, triage results, and keep track of articles of interest. The tool implements an innovative “sifter” functionality for relevance ranking, giving the researcher a way to find articles of interest quickly. The tool also gives researchers a view of the literature for a set of entities and could also be useful for meta-research analyses. The Abstract Sifter is available as a Microsoft Excel macro-enabled workbook application.