Irreproducibility in Preclinical Biomedical Research: Perceptions, Uncertainties and Knowledge Gaps.
Over the last years, many articles and commentaries were written about the ‘reproducibility of research data’. In this new paper, Jarvis and Williams provide a very refreshing view arguing that ‘perceptions of research irreproducibility in the preclinical sciences are based on limited, frequently anecdotal data from select therapeutic areas of cell and molecular biology’. This statement clearly indicates where the urgent need is today. Indeed, besides some limited number of analyses done on real data and theoretical considerations, hard evidence is often missing. In the absence of this information, there is a danger that emerging efforts in the field of ‘reproducibility’ have a ‘potential to inhibit scientific innovation’, as noted by Jarvis and Williams (Trends Pharmacol Sci. 2016. doi: 10.1016/j.tips.2015.12.001