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Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

The Reproducibility Project: Cancer Biology aims to replicate a number of landmark studies in the field of tumor biology published between 2010 – 2012. The latest replication attempt was published on March 12thin eLIFE and focused on a publication from 2011 by Liu et al. The attempt to …

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Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

Scientific articles using cell lines, which are registered on the International Cell Line Authentication Committee (ICLAC) or the Cellosaurus database as ‘misidentified’ continue to be published. Often, the routinely use of short-tandem repeat profiling to test for contamination is not implemented as a standard procedure. Research …

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Why we need to report more than ’Data were Analyzed by t-tests or ANOVA’

In this article,Weissgerber et al. present findings suggesting that scientific publications are often lacking sufficient information about the statistical methods used, which are required by independent scientists to successfully replicate the published results. The authors evaluated the quality of reporting of statistical tests (such as t-tests and …

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How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Reproducibility in preclinical research may be low because of the high prevalence of biases and of suboptimal research practices (such as biased allocation of experimental groups, experimenter bias and lack of necessary controls, the use of uncharacterized materials, poor use of statistics, poor scientific training, etc.). …

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