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Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

Today, the probability of successfully publishing negative/null results in biomedical research is lower than that for positive results. For instance, negative results repeatedly remain in lab books or drawers, or are not being published because they are rejected by scientific journals. These seemingly positive results then …

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Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

As part of the Reproducibility Project: Cancer Biology, this report describes the attempt to replicate critical experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota” (Arthur et al., 2012). In agreement with the original study, the authors did not observe any changes on …

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Researcher Requests for Inappropriate Analysis and Reporting: A U.S. Survey of Consulting Biostatisticians

In this report, Wang and colleagues present the results of a national survey of nearly 400 consulting statisticians about requests from investigators to engage in inappropriate statistical practices. The four most frequently reported inappropriate requests were (in order of frequency): a) removing or altering some data …

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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

At the presentation of the ECNP Negative Data Award (see above), there was an interesting point made by one of the presenters – about the important role of large multi-national multi-lab collaboration projects for the scientific progress. More specifically, it was emphasized that initiatives such as …

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