In: Literature
Re-evaluation of failed drugs and targets using contemporary knowledge, methodology and tools
July 22, 2016Co-authored by PAASP’s managing partner, Anton Bespalov, the correspondence article ‘Failed trials for central nervous system disorders do not necessarily invalidate…
Read MoreWhy Most Clinical Research Is Not Useful.
June 30, 2016In this essay, John P.A. Ioannidis argues that features relating to problem base, context placement, information gain, pragmatism, patient centeredness, value…
Read MorePublications June 2016
June 22, 2016Reproducibility Crisis: Are We Ignoring Reaction Norms? In this letter, published in Trends in Pharmacological Sciences, Bernhard Voelkl and Hanno Würbel…
Read More1,500 scientists lift the lid on reproducibility
May 26, 2016According to the survey conducted by Nature (link), more than 52% of 1,576 researchers representing different areas of science see a…
Read MorePublications May 2016
May 22, 2016Innovative Medicine Initiative (IMI) Announcement: On 27 April 2016 IMI officially launched its 9th Call for proposals under IMI 2. It…
Read MoreDevelopment of an information sharing platform – Pharma shares unpublished results
May 22, 2016F1000 Research has published an article entitled “In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreThe Experiment Factory: Standardizing Behavioral Experiments
April 26, 2016Vanessa V. Sochat and colleagues from Stanford University have presented the Experiment Factory, a modular infrastructure that applies a collaborative, open source…
Read MorePublications April 2016
April 22, 2016Statement on Statistical Significance and P-values. The world’s largest professional association of statisticians, the American Statistical Association, has made a public…
Read MoreIn search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis
April 11, 2016Intravenous ketamine has been repeatedly shown to induce a rapid and long-lasting antidepressant effect in treatment-resistant patients. A 2010 Science paper…
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