In this essay, John P.A. Ioannidis argues that features relating to problem base, context placement, information gain, pragmatism, patient centeredness, value for money, feasibility, and transparency define useful clinical research. As many studies do not satisfy these criteria, he concludes that most clinical research is not useful and reform is overdue. Importantly, he points out that clinical researcher shouldn’t be held responsible, but instead the issue of non-useful research should be seen as an opportunity to improve and to engage many other stakeholders, including funding agencies, the industry, journals and patients. ‘Joint efforts by multiple stakeholders may yield solutions that are more likely to be more widely adopted and thus successful.’ Read more.