Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved by publishers in six key areas: (1) understanding researchers’ problems and motivations; (2) raising awareness of issues and encouraging behavioural and cultural change; (3) improving the quality and objectivity of the peer-review process; (4) improving scholarly communication infrastructure, promoting study registration, partnering with data repositories and providing services that improve data sharing and data curation; (5) increasing incentives for practising open research; and (6) making research communication more open and accessible. This Handbook of Experimental Pharmacology chapter by Iain Hrynaszkiewicz describes practical approaches being taken by publishers, in these six areas, their progress and effectiveness and the implications for researchers publishing their work.