One year after Global Biological Standards Institute (GBSI) issued its Reproducibility2020 challenge and action plan for the biomedical research community, Freedman et al. (President GBSI) report encouraging progress toward the goal to significantly improve the quality of preclinical biological research by year 2020. The Report is a comprehensive review of community-led action and impact to improve life sciences research reproducibility since the issue became more widely known in 2012. In addition, it contains specific actions that each stakeholder group can take to enhance reproducibility.