By: Anton Bespalov

“Blinding in histopathology assessments – I see your point but…”
June 16, 2022

We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…

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How much power should my next study have: One size fits all?
March 14, 2022

There is a slow but steady increase in the number of publications where authors report on sample size justification.  In most…

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Pre-study odds
March 14, 2022

One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…

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Illustrating the role of PPV, power and sample size with an R script
March 8, 2022

This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott

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The “from-quality-to-system” pendulum
December 20, 2021

by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…

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Of peer review and data sharing
November 3, 2021

 We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…

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“Don’t cut the tree you are sitting on!”
November 3, 2021

According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…

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Aducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

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The EQIPD Workshop “Rigor, reproducibility and data management in nonclinical research”
June 16, 2021

On 21 April 2021 a virtual EQIPD workshop entitled “Rigor, reproducibility and data management in nonclinical research” was organized in Finland…

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The EQIPD principles
June 16, 2021

The EQIPD Toolbox now contains a set of principles, which may help scientists, stakeholders and users to better understand what the…

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