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Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

As part of the Reproducibility Project: Cancer Biology, this report describes the attempt to replicate critical experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota” (Arthur et al., 2012). In agreement with the original study, the authors did not observe any changes on …

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Researcher Requests for Inappropriate Analysis and Reporting: A U.S. Survey of Consulting Biostatisticians

In this report, Wang and colleagues present the results of a national survey of nearly 400 consulting statisticians about requests from investigators to engage in inappropriate statistical practices. The four most frequently reported inappropriate requests were (in order of frequency): a) removing or altering some data …

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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

At the presentation of the ECNP Negative Data Award (see above), there was an interesting point made by one of the presenters – about the important role of large multi-national multi-lab collaboration projects for the scientific progress. More specifically, it was emphasized that initiatives such as …

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To Have Practical Relevance, Scientific Claims Need to be Accurate

For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is important that scientific claims are as accurate as possible. However, there is increasing evidence questioning the robustness and accuracy of social and biomedical research outcomes. …

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A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

The ARRIVE guidelines are widely endorsed but compliance is limited. The IICARus Collaboration group sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines. In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March-June …

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