Evaluation of recombinant monoclonal antibody SVmab1 binding to NaV1.7 target sequences and block of human NaV1.7 currents

September 12, 2016

The Preclinical Reproducibility & Robustness (PRR) channel provides a venue for researchers to publish both confirmatory and non-confirmatory studies to help improve…

Statement by Martin Michel

September 9, 2016

“In God we trust” is minted on each US coin. The evidence-based medicine movement has adapted this to “In God we…

A proposal for validation of antibodies.

September 5, 2016

The International Working Group on Antibody Validation (IWGAV) is an independent group of international scientists with diverse research interests in the…

A STAR Is Born

August 25, 2016

A STAR Is Born – Cell Press transforms the methods section of articles to improved transparency and accessibility. As one of the…

Accurate design of in vitro experiments – why does it matter?

August 24, 2016

Good statistical design is a key aspect of meaningful research. Elements such as data robustness, randomization and blinding are widely recognized…

Searching for significance

August 20, 2016

To examine associations between urinary chemical concentrations and adult health status, the US Centers for Disease Control and Prevention (CDC) measured…

Retraction notice:

August 17, 2016

‘…There was no response from the authors despite our attempts to reach them and request to clarify these discrepancies. More importantly,…

Mouse microbes may make scientific studies harder to replicate.

August 16, 2016

“Microbiome” is a term used to refer to gut bacteria but also to other inhabitants of the gut, like viruses, fungi,…

From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer’s disease mouse models.

August 10, 2016

Systematic review and meta-analysis are powerful tools to assess the validity and robustness of data published in a certain research field….

Decision-enabling studies: Robust enough to support critical decisions?