“Blinding in histopathology assessments – I see your point but…”
June 16, 2022We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…
Read MoreArchimedes‘ fulcrum and the “reproducibility” debate
June 16, 2022We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…
Read More“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022When it comes to novel therapies, positive data has justifiably more value than negative or null data. Indeed, positive data promises…
Read MoreAdditional reads in June 2022
June 16, 2022European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done? ‘Robot scientist’…
Read MoreConsiderations for implementing electronic laboratory notebooks in an academic research environment
June 16, 2022Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…
Read MoreMany researchers were not compliant with their published data sharing statement: mixed-methods stud
June 16, 2022In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…
Read MoreBlind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…
Read MoreDo multiple experimenters improve the reproducibility of animal studies?
June 16, 2022In light of the reproducibility crisis, there is a growing awareness that the rigorous standardization of experimental conditions may contribute to…
Read MoreTesting the reproducibility and robustness of the cancer biology literature by robot
June 16, 2022Scientific results should be reproducible and robust. However, when reproducibility is tested, it is often not found (often termed ’reproducibility crisis’),…
Read MoreWhat has preclinical systematic review ever done for us?
June 16, 2022Systematic reviews and meta-analyses deliver a crystallized understanding of the existing research data in any given space. However, grappling with the…
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