In: Commentaries

“Publication of negative/null results discussed at NIH”
November 2, 2022

NINDS Office of Research Quality has presented a proposal on how to address the publication bias. It can be watched HERE (starts at…

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“The customer is king!” 
November 2, 2022

Once during our vacation in Greece, our children asked for ice cream after having dinner.  When the waiter was asked about…

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“Hold your horses!”
November 2, 2022

Risk of Alzheimer’s disease nearly doubles in older adults with Covid-19!  Like many of you, several weeks ago we have also…

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“The Steal syndrome – or the FDA Modernization Act to end animal testing requirement passes U.S. Senate”
November 2, 2022

On September 29, 2022, the U.S. Senate passed the FDA Modernization Act 2.0, S.5002, by unanimous consent. While it is unclear…

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Archimedes‘ fulcrum and the “reproducibility” debate
June 16, 2022

We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…

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“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022

When it comes to novel therapies, positive data has justifiably more value than negative or null data.  Indeed, positive data promises…

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Pre-study odds
March 14, 2022

One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…

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Preparing for a journey
February 27, 2022

Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…

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The “from-quality-to-system” pendulum
December 20, 2021

by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…

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Of peer review and data sharing
November 3, 2021

 We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…

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