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“Avoiding the Edge Effect – How to increase reproducibility of in vitro microplate experiments?”

The randomization of study subjects is commonly discussed for in vivo studies and is in general an accepted practice. However, for in vitro experiments, randomization is often seen by scientists as unnecessary effort with questionable impact.In our Featured Publication, an assay artefact called Edge Effect was identified as a …

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Invited Commentary: Qeios – from a powerful writing tool to an immidiate Open Access platform

By Gabriele MarinelloCo-founder, Qeios We have just started with Qeios the path towards the necessary revolution in research production, quality check and sharing.We have built an astonishingly simple integrated system which combines those three distinct phases of the research life-cycle. Besides being freely accessible to everyone, simpler and …

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MANILA – A web tool for designing reproducible and transparent preclinical intervention studies

Teemu D. Laajala1,21: University of Turku, Turku (Finland), Department of Mathematics and Statistics2: University of Colorado, Denver (CO, US), Anschutz Medical Campus, Department of Pharmacology MANILA (MAtched ANimaL Analysis) is a novel web-based tool that leverages predictive baseline variables and incorporates complex baseline characteristics for allocating treatment …

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private forever

There is growing awareness about the values of preregistered studies or key elements thereof. And there is a growing number of online resources that offer preregistration services. Some preregistration platforms are aimed to serve any area of science, others focus on specific fields (e.g. animal research). …

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Promoting transparency in preclinical research: preregistration of animal study protocols on www.preclinicaltrials.eu

Smit NW1, Van der Naald M2,3, Wever KE4, Duncker DJ1,5, Chamuleau SAJ2,3,6   1Netherlands Heart Institute, The Netherlands 2University Medical Center Utrecht, The Netherlands 3Member of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes 4SYRCLE, Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands 5Erasmus Medical Center, The …

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