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To Have Practical Relevance, Scientific Claims Need to be Accurate

For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is important that scientific claims are as accurate as possible. However, there is increasing evidence questioning the robustness and accuracy of social and biomedical research outcomes. …

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Guidelines on statistics for researchers using laboratory animals: the essentials

There is a growing concern that flawed statistics and deficient reproducibility in biomedical studies results in an unethical waste of animals in research. This review by Romain-Daniel Gosselin aims to provide guidelines in biostatistics for researchers, based on frequently observed mistakes, misuses and misconceptions as well …

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A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

The ARRIVE guidelines are widely endorsed but compliance is limited. The IICARus Collaboration group sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines. In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March-June …

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