All Posts by ‘Christoph Emmerich’
Thoughts on How Institutions Can Promote a Culture of Research Integrity
By Dr. Michael Lauer (NIH) Link to web page
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
Use of high-quality tools is an essential element of Good Research Practice. Like for many other aspects, “high quality” is a relative term suggesting that the tools are fit-for-purpose according to the best information available today.A recent paper by Lin and colleagues illustrates that, with the …
Toward Good In Vitro Reporting Standards
Many areas of biomedical science have developed reporting standards and checklists to support the adequate reporting of scientific efforts, but in vitro research still has no generally accepted criteria. In this article, the authors discuss ‘focus points’ of in vitro research, ensuring that the scientific community …
Reproducible and Transparent Research Practices in Published Neurology Research
Four erroneous beliefs thwarting more trustworthy research
A range of problems currently undermines public trust in biomedical research. In this article, Mark Yarborough and colleagues discuss four erroneous beliefs that may prevent the biomedical research community from recognizing the need to focus on deserving this trust, and which can act as powerful barriers …
Laboratory mice born to wild mice have natural microbiota and model human immune responses
Presentation of the newly developed Guidelines On Target Validation for Innovative Therapeutics (GOT-IT)
Representing the GOT-IT Team, Christoph Emmerich presented the GOT-IT Guidelines at the “BMBF Vernetzungstreffen zur Nationalen Wirkstoffinitiative” on the 8th of October 2019, which was attended by academic PIs, industry representatives, officials from the Federal Ministry of Education and Research and members of the German Parliament.Furthermore, PAASP …
License to Kill – From Killer Experiments and Synthetic Lethality
The Maternal Embryonic Leucine zipper Kinase (MELK) is an interesting enzyme:In 2005, MELK was first implicated in cancer by finding elevated levels of MELK RNA expression in many human tumors (REF1). Since the initial article, another 32 articles have been published that specifically implicate MELK as …