In: Case Study

Estimation vs Hypothesis-Testing
November 22, 2019

As some of our readers may know, the PAASP team was involved in the “Negative results Award” project that took place…

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License to Kill – From Killer Experiments and Synthetic Lethality
August 12, 2019

The Maternal Embryonic Leucine zipper Kinase (MELK) is an interesting enzyme:In 2005, MELK was first implicated in cancer by finding elevated…

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Something is rotten in the state of antibody quality
March 11, 2019

A team of researchers led by Eleftherios P. Diamandis at the University of Toronto set out to discover novel serological markers…

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The SOD1 mouse – 10 years later
December 20, 2018

It has been more than 10 years since two seminal papers by Ludolph et al (2007) and Scott et al (2008) have introduced recommendations for…

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Reporting details – Differential induction of innate immune responses by LPS
November 17, 2018

The importance of reporting small details and making well-informed decisions about which information to include for each experimental parameter/factor in scientific…

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“Andromeda and Orion of modern biomarker research”
September 10, 2018

Amyloid beta (Aß) accumulation in the brain is regarded as one of the histopathological hallmarks of Alzheimer’s disease. However, Aß build-up…

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Reproducibility Issues – The Ghosts of HeLa
July 9, 2018

Listeria monocytogenes is an intracellular pathogen and the causative agent of the food-borne disease listeriosis. This disease primarily affects pregnant women,…

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Heads I win, tails you lose
June 6, 2018

Preclinical in vivo scientists often have to deal with a very interesting situation: Imagine we design a study to demonstrate that…

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Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
June 6, 2018

As part of the “Reproducibility Project: Cancer Biology”, a Registered Report (Repass et al., 2016) was published in 2016, that described…

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Make hay while the sun shines
January 23, 2018

“When she arrived, I gave her a data set of a self-funded, failed study which had null results (it was a…

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