As part of the “Reproducibility Project: Cancer Biology”, a Registered Report (Repass et al., 2016) was published in 2016, that described how to replicate an experiment from the paper “Fusobacterium nucleatuminfection is prevalent in human colorectal carcinoma” (Castellarin et al., 2012). Here, the “Reproducibility Project: Cancer …
In the November issue of our Newsletter, we have featured a publication by the NPQIP Collaborative Group (LINK) that analyzed the impact of the Nature journals’ “checklists” for life sciences research on the completeness of reporting of the “Landis 4” items (randomization, blinding, sample size calculation, …
In biomedical research, dealing with probabilities is part of the daily routine for many scientists, independently of their specific research area. Statistics and probability calculations are important during the design phase of experiments (e.g., for group size calculation and power estimations), as well as during the …
All Case Study publications presented in this section have received a lot of interest among the scientific community and are particularly interesting from a GSP perspective. These case studies demonstrate the need for a high-quality study design, including the incorporation of basic GSP standards and guidelines, …
Glyphosate, or N-(phosphonomethyl)glycine, is a widely used broad-spectrum, nonselective herbicide that has been in use since 1974. Glyphosate effectively suppresses the growth of many species of trees, grasses, and weeds. It acts by interfering with the synthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, …
We will continue presenting Case Study publications that are particularly interesting from the Good Research Practice perspective. We hope that these cases can be useful in training programs and will help younger scientists to learn about the basics of study design, planning and analysis. We invite …
To examine associations between urinary chemical concentrations and adult health status, the US Centers for Disease Control and Prevention (CDC) measured the urine of 1455 study participants (representing the general US adult population) for the presence of 275 environmental chemicals, including Bisphenol A (BPA). BPA is …
