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Heads I win, tails you lose

Preclinical in vivo scientists often have to deal with a very interesting situation: Imagine we design a study to demonstrate that “our” drug can exert certain pharmacodynamic activity. As it unfortunately happens rather often, we design this study to include only one dose of our drug …

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Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

As part of the “Reproducibility Project: Cancer Biology”, a Registered Report (Repass et al., 2016) was published in 2016, that described how to replicate an experiment from the paper “Fusobacterium nucleatuminfection is prevalent in human colorectal carcinoma” (Castellarin et al., 2012). Here, the “Reproducibility Project: Cancer …

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The Birthday Paradox

In biomedical research, dealing with probabilities is part of the daily routine for many scientists, independently of their specific research area. Statistics and probability calculations are important during the design phase of experiments (e.g., for group size calculation and power estimations), as well as during the …

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