In: Commentaries
“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022When it comes to novel therapies, positive data has justifiably more value than negative or null data. Indeed, positive data promises…
Read MorePre-study odds
March 14, 2022One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…
Read MorePreparing for a journey
February 27, 2022Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…
Read MoreThe “from-quality-to-system” pendulum
December 20, 2021by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…
Read MoreOf peer review and data sharing
November 3, 2021We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…
Read More“Don’t cut the tree you are sitting on!”
November 3, 2021According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…
Read MoreHow to See More Clearly in the Lab?
June 16, 2021When you can see the world clearly, it’s easy to get where you want to go: You might still get where…
Read MoreAducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…
Read MorePseudoreplication in Physiology – more means less
March 30, 2021Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…
Read MoreLet’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…
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