EDUCATIONAL CORNER
Guidelines in Research
Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…
Read MorePAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreGuidelines for target validation published
November 16, 2020The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…
Read MoreThe Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…
Read MoreCase Studies
Careful interpretation of Western blotting data
February 23, 2021Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…
Read MoreIn vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreBest-dose analysis – A confirmatory research case
August 17, 2020It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments. These…
Read MoreBeauty is not everything
May 28, 2020Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
Reference Collection to push back against “Common Statistical Myths”
December 20, 2021In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…
Read MoreA wiki platform to support the organization of research labs
November 3, 2021As part of the PREMIER project, a document sharing system was developed and made freely available as a template to all interested parties…
Read MoreNINDS Rigor Resources
November 3, 2021The National Institute on Neurological Disorders and Stroke (NINDS) has been gathering a list of currently available public resources that are, or can…
Read MoreMaterials Design Analysis Reporting (MDAR) Reports via SciScore
November 3, 2021We have recently introduced the Materials, Design, Analysis, and Reporting (MDAR) framework aiming at helping authors, editors, and other interested parties to increase…
Read MoreNew Publications
Additional Reads in December 2021
December 20, 2021Want research integrity? Stop the blame game Einstein Foundation Award 2021 Understand the real reasons reproducibility reform fails Five keys to…
Read MoreNonreplicable publications are cited more than replicable ones
December 20, 2021In this article, Marta Serra-Garcia and Uri Gneezy used publicly available data to show that published papers in top psychology, economics,…
Read MoreInvestigating the replicability of preclinical cancer biology
December 20, 2021Replicability is an important feature of scientific research. Thus, the Reproducibility Project: Cancer Biology was set up to provide evidence about…
Read MoreMisidentified biomedical resources: Journal guidelines are not a quick fix
December 20, 2021Some journals have implemented guidelines regarding the use and reporting of cell lines, antibodies, and laboratory animals to improve the value…
Read MoreCommentaries
The “from-quality-to-system” pendulum
December 20, 2021by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…
Read MoreOf peer review and data sharing
November 3, 2021We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…
Read More“Don’t cut the tree you are sitting on!”
November 3, 2021According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…
Read MoreHow to See More Clearly in the Lab?
June 16, 2021When you can see the world clearly, it’s easy to get where you want to go: You might still get where…
Read MoreFun Section
A method to streamline p-hacking
June 16, 2021The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…
Read MoreScaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreAll Posts
Experiences with the EQIPD QS
January 20, 2022María Arroyo-Araujo and Martien J.H. Kas published an article in which they describe the advantages of having implemented the EQIPD Quality…
Read MoreNEWSLETTER December 2021
December 20, 2021EQIPD News Update EQIPD Toolbox: Item “1.4.3.5 Expectations from public funders” – Read more New EQIPD-certified research unit – Read more…
Read MoreReference Collection to push back against “Common Statistical Myths”
December 20, 2021In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…
Read MoreThe “from-quality-to-system” pendulum
December 20, 2021by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…
Read More