EDUCATIONAL CORNER
Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreGuidelines for target validation published
November 16, 2020The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…
Read MoreThe Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…
Read MoreImpact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…
Read MoreCase Studies
Careful interpretation of Western blotting data
February 23, 2021Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…
Read MoreIn vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreBest-dose analysis – A confirmatory research case
August 17, 2020It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments. These…
Read MoreBeauty is not everything
May 28, 2020Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…
Read MoreHow to organize data in a spreadsheet?
December 18, 2020Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…
Read MoreSuccessful adaption of the EQIPD Quality System to specific research needs
December 18, 2020The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…
Read MoreTen simple rules on how to write a standard operating procedure
October 8, 2020The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…
Read MoreNew Publications
Additional reads in March 2021
March 30, 2021Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…
Read MoreReactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…
Read MoreTaking a fresh look at FAIR for research software
March 30, 2021Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…
Read MoreAdvancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…
Read MoreCommentaries
WANTED – Cartoon artist
March 30, 2021We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…
Read MorePseudoreplication in Physiology – more means less
March 30, 2021Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…
Read MoreLet’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…
Read MoreFive rules for evidence communication
December 18, 2020Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…
Read MoreFun Section
Scaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreFun Section January 2020
February 1, 2020A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…
Read MoreParachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
December 18, 2019Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.Design: Randomized controlled trial.Setting: Private or commercial…
Read MoreAll Posts
Newsletter March 2021
March 30, 2021NEWS from the PAASP network – New series of EQIPD lectures – Read more …
Read MoreA teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…
Read MoreWANTED – Cartoon artist
March 30, 2021We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…
Read MorePseudoreplication in Physiology – more means less
March 30, 2021Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…
Read More