EDUCATIONAL CORNER
Guidelines in Research
Bringing microscopy images to the next level
June 16, 2022In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…
Read MoreThe MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences
March 14, 2022The MDAR working group came together in late 2017 with the intention to develop a framework to promote transparent reporting, with…
Read MoreToward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…
Read MorePAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreCase Studies
“Blinding in histopathology assessments – I see your point but…”
June 16, 2022We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…
Read MoreHow much power should my next study have: One size fits all?
March 14, 2022There is a slow but steady increase in the number of publications where authors report on sample size justification. In most…
Read MoreCareful interpretation of Western blotting data
February 23, 2021Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…
Read MoreIn vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…
Read MorePreregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu
June 16, 2022Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…
Read MoreIllustrating the role of PPV, power and sample size with an R script
March 8, 2022This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott
Read MoreReference Collection to push back against “Common Statistical Myths”
December 20, 2021In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…
Read MoreNew Publications
Additional reads in June 2022
June 16, 2022European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done? ‘Robot scientist’…
Read MoreConsiderations for implementing electronic laboratory notebooks in an academic research environment
June 16, 2022Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…
Read MoreMany researchers were not compliant with their published data sharing statement: mixed-methods stud
June 16, 2022In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…
Read MoreBlind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…
Read MoreCommentaries
Archimedes‘ fulcrum and the “reproducibility” debate
June 16, 2022We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…
Read More“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022When it comes to novel therapies, positive data has justifiably more value than negative or null data. Indeed, positive data promises…
Read MorePre-study odds
March 14, 2022One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…
Read MorePreparing for a journey
February 27, 2022Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…
Read MoreFun Section
A method to streamline p-hacking
June 16, 2021The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…
Read MoreScaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreAll Posts
The EQIPD Quality System was presented at the World Conference on Research Integrity
June 16, 2022The World Conference on Research Integrity in 2022 happened in Cape Town, South Africa from May 29 to June 01. The…
Read MoreFirst International Society for Preclinical Research Quality Systems Launched
June 16, 2022The Guarantors of EQIPD e.V. (GoEQIPD) announce the formation of a registered association, registered in Heidelberg Germany, to host and to ensure…
Read MoreEQIPD-PAASP working relationship
June 16, 2022As an important step forward in the evolution of the EQIPD quality system for preclinical research, the Guarantors of EQIPD and the PAASP Network are…
Read MoreNewsletter June 2022
June 16, 2022News First International Society for Preclinical Research Quality Systems Launched – Read more EQIPD-PAASP working relationship – Read more The EQIPD…
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