EDUCATIONAL CORNER
Guidelines in Research
Recommendations to improve use and reporting of statistics in animal experiments
December 22, 2023Flaws in experimental statistics are a major contributor to the poor reproducibility of animal experiments. Informed decisions about whether conclusions are…
Read MoreCo-creating Research Integrity Education Guidelines for Research Institutions
December 22, 2023To support institutions to foster research integrity (RI), Krishma Labib and colleagues developed RI education guidelines together with RI experts and…
Read MoreCell line authentication: a necessity for reproducible biomedical research
November 2, 2022Immortalized or continuous cell lines are invaluable tools in basic and preclinical research. However, the widespread use of misidentified cell lines…
Read MoreDesigning and implementing a research integrity promotion plan: Recommendations for research funders
November 2, 2022Various stakeholders in science have put research integrity high on their agenda. Among them, research funders are prominently placed to foster…
Read MoreCase Studies
“Blinding in histopathology assessments – I see your point but…”
June 16, 2022We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…
Read MoreHow much power should my next study have: One size fits all?
March 14, 2022There is a slow but steady increase in the number of publications where authors report on sample size justification. In most…
Read MoreCareful interpretation of Western blotting data
February 23, 2021Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…
Read MoreIn vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
Intentional misconduct or too busy to oversee the lab?
December 23, 2024The recent scientific misconduct in the laboratories of Eliezer Masliah is not the first such case and will unfortunately most likely…
Read MoreA qualitative study of the barriers to using blinding in in vivo experiments and suggestions for improvement
December 22, 2023In animal experiments, blinding is a methodological strategy to reduce the risk that scientists, animal care staff, or other staff involved…
Read MoreAdvanced methods and implementations for the meta-analyses of animal models: Current practices and future recommendations
December 22, 2023Meta-analytic techniques have been widely used to synthesize data from animal models of human diseases and conditions, but these analyses often…
Read MoreDesigning, conducting, and reporting reproducible animal experiments
December 22, 2023In this review, Emma Wilson and colleagues aim to engage researchers in the discussion on research reproducibility and to provide the…
Read MoreNew Publications
Additional Reads in December 2023
December 22, 2023Further commentaries, articles and blog posts worth reading:Zen und die Kunst, Forschung zu bewerten (in German) In defense of quantitative metrics…
Read MoreEffects of ketamine optical isomers, fluoxetine and naloxone on timing in differential reinforcement of low-rate response (DRL) 72-s task in rats
December 22, 2023This is one of the first publications reporting the results of original research performed in an EQIPD-certified laboratory. This study was…
Read MoreSystematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites
December 22, 2023The influence of protocol standardization between laboratories on their replicability of preclinical results has not been addressed in a systematic way….
Read MoreSex as a biological variable in preclinical research: Unforeseen and abused degree of freedom
December 21, 2023In many fields of biomedical research, in vivo studies traditionally involved the use of male subjects. The situation recently started to…
Read MoreCommentaries
Commentary: What if …
December 23, 2024Several years ago we discussed potential scenarios related to the outcome of Cassava’s Phase 3 program. To remind our readers, concerns…
Read MoreIntentional misconduct or too busy to oversee the lab?
December 23, 2024The recent scientific misconduct in the laboratories of Eliezer Masliah is not the first such case and will unfortunately most likely…
Read MoreImagine…
December 23, 2024… you go to a supermarket or a grocery store, buy everything you need, pay at the cashier’s but leave all…
Read MoreDon’t throw the baby out with the bathwater
December 22, 2023The pressure to replace animal research with non-animal methods is growing. Earlier this year, NIH has issued a “Request for Information…
Read MoreFun Section
A method to streamline p-hacking
June 16, 2021The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…
Read MoreScaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreAll Posts
Upcoming Webinar: Financing of biomedical innovation
January 24, 2025January, 31st, 2025 | Hosted by ECNP Preclinical Data Forum Network With recent high-profile misconduct cases—like that of Eliezer Masliah—raising concerns…
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