EDUCATIONAL CORNER
Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreGuidelines for target validation published
November 16, 2020The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…
Read MoreThe Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…
Read MoreImpact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…
Read MoreCase Studies
In vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreBest-dose analysis – A confirmatory research case
August 17, 2020It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments. These…
Read MoreBeauty is not everything
May 28, 2020Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…
Read MoreCovid-19 and the PPV
May 28, 2020There has been a lot in the news recently about using antibody tests to detect people who have had Covid-19 and…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
How to organize data in a spreadsheet?
December 18, 2020Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…
Read MoreSuccessful adaption of the EQIPD Quality System to specific research needs
December 18, 2020The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…
Read MoreTen simple rules on how to write a standard operating procedure
October 8, 2020The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…
Read MoreEQIPD: PAASP’s contribution to the new Quality System for preclinical research
October 8, 2020EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…
Read MoreNew Publications
ADDITIONAL READS IN DECEMBER 2020
December 18, 2020Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…
Read MoreHow often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…
Read MorePublication rate in preclinical research: a plea for preregistration
December 18, 2020In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….
Read MoreUse of causal claims in observational studies: a research on research study
December 18, 2020Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…
Read MoreCommentaries
Five rules for evidence communication
December 18, 2020Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…
Read MoreThe Costs of Competitiveness
December 18, 2020In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…
Read MoreA time to cast away stones, and a time to gather stones together
December 18, 2020Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…
Read MoreViolation of research integrity by selective citation
October 8, 2020We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…
Read MoreFun Section
Scaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreFun Section January 2020
February 1, 2020A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…
Read MoreParachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
December 18, 2019Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.Design: Randomized controlled trial.Setting: Private or commercial…
Read MoreAll Posts
Newsletter December 2020
December 18, 2020NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…
Read MoreHow to organize data in a spreadsheet?
December 18, 2020Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…
Read MoreFive rules for evidence communication
December 18, 2020Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…
Read MoreThe Costs of Competitiveness
December 18, 2020In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…
Read More