EDUCATIONAL CORNER

A carefully curated collection of news and resources relevant to our favorite topics.

Guidelines in Research
Bringing microscopy images to the next level
June 16, 2022

In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…

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The MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences
March 14, 2022

The MDAR working group came together in late 2017 with the intention to develop a framework to promote transparent reporting, with…

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Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021

With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…

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PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Case Studies
“Blinding in histopathology assessments – I see your point but…”
June 16, 2022

We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…

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How much power should my next study have: One size fits all?
March 14, 2022

There is a slow but steady increase in the number of publications where authors report on sample size justification.  In most…

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Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Editorials
PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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eNeuro publishes Series on Scientific Rigor
July 22, 2016

Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…

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An incentive-based approach for improving data reproducibility
April 29, 2016

In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…

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Tools for researchers
Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

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Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu
June 16, 2022

Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…

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Illustrating the role of PPV, power and sample size with an R script
March 8, 2022

This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott

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Reference Collection to push back against “Common Statistical Myths”
December 20, 2021

In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…

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New Publications
Additional reads in June 2022
June 16, 2022

European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done?  ‘Robot scientist’…

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Considerations for implementing electronic laboratory notebooks in an academic research environment
June 16, 2022

Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…

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Many researchers were not compliant with their published data sharing statement: mixed-methods stud
June 16, 2022

In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…

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Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

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Commentaries
Archimedes‘ fulcrum and the “reproducibility” debate
June 16, 2022

We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…

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“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022

When it comes to novel therapies, positive data has justifiably more value than negative or null data.  Indeed, positive data promises…

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Pre-study odds
March 14, 2022

One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…

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Preparing for a journey
February 27, 2022

Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…

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Fun Section
Support by artificial intelligence
November 3, 2021

https://xkcd.com/2494/ Read More
A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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All Posts
The EQIPD Quality System was presented at the World Conference on Research Integrity
June 16, 2022

The World Conference on Research Integrity in 2022 happened in Cape Town, South Africa from May 29 to June 01. The…

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First International Society for Preclinical Research Quality Systems Launched
June 16, 2022

The Guarantors of EQIPD e.V. (GoEQIPD) announce the formation of a registered association, registered in Heidelberg Germany, to host and to ensure…

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EQIPD-PAASP working relationship
June 16, 2022

As an important step forward in the evolution of the EQIPD quality system for preclinical research, the Guarantors of EQIPD and the PAASP Network are…

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Newsletter June 2022
June 16, 2022

News First International Society for Preclinical Research Quality Systems Launched – Read more EQIPD-PAASP working relationship – Read more  The EQIPD…

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