EDUCATIONAL CORNER
Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreGuidelines for target validation published
November 16, 2020The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…
Read MoreThe Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…
Read MoreImpact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…
Read MoreCase Studies
Careful interpretation of Western blotting data
February 23, 2021Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…
Read MoreIn vivo veritas
October 5, 2020Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…
Read MoreBest-dose analysis – A confirmatory research case
August 17, 2020It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments. These…
Read MoreBeauty is not everything
May 28, 2020Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…
Read MoreEditorials
PAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreeNeuro publishes Series on Scientific Rigor
July 22, 2016Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…
Read MoreAn incentive-based approach for improving data reproducibility
April 29, 2016In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…
Read MoreTools for researchers
What is the optimum design for my animal experiment?
June 16, 2021Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…
Read MoreThe MDAR Framework – a new tool for life sciences reporting
June 16, 2021Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…
Read MoreEQIPD Quality System published
June 16, 2021The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…
Read MoreA teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…
Read MoreNew Publications
Additional reads in June 2021
June 16, 2021Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…
Read MorePutting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…
Read MoreCreating clear and informative image-based figures for scientific publications
June 16, 2021Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…
Read MoreWhat is the optimum design for my animal experiment?
June 16, 2021Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…
Read MoreCommentaries
How to See More Clearly in the Lab?
June 16, 2021When you can see the world clearly, it’s easy to get where you want to go: You might still get where…
Read MoreAducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…
Read MoreWANTED – Cartoon artist
March 30, 2021We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…
Read MorePseudoreplication in Physiology – more means less
March 30, 2021Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…
Read MoreFun Section
A method to streamline p-hacking
June 16, 2021The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…
Read MoreScaling the y-axis
May 29, 2020One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…
Read MoreFun, fun, fun…
March 31, 2020A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…
Read MoreFun Section January 2020
February 1, 2020A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…
Read MoreAll Posts
Webinar at scientist.com
June 21, 2021PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…
Read MoreNewsletter June 2021
June 16, 2021NEWS – New EQIPD paper published – Read more – The MDAR Framework –…
Read MoreA method to streamline p-hacking
June 16, 2021The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…
Read MoreHow to See More Clearly in the Lab?
June 16, 2021When you can see the world clearly, it’s easy to get where you want to go: You might still get where…
Read More