EDUCATIONAL CORNER

A carefully curated collection of news and resources relevant to our favorite topics.

Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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Case Studies
Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Beauty is not everything
May 28, 2020

Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…

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Editorials
PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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eNeuro publishes Series on Scientific Rigor
July 22, 2016

Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…

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An incentive-based approach for improving data reproducibility
April 29, 2016

In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…

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Tools for researchers
A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Successful adaption of the EQIPD Quality System to specific research needs
December 18, 2020

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

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Ten simple rules on how to write a standard operating procedure
October 8, 2020

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

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New Publications
Additional reads in March 2021
March 30, 2021

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

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Reactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

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Taking a fresh look at FAIR for research software
March 30, 2021

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Commentaries
WANTED – Cartoon artist
March 30, 2021

We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…

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Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

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Let’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021

by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…

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Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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Fun Section
Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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Fun Section January 2020
February 1, 2020

A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…

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Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
December 18, 2019

Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.Design: Randomized controlled trial.Setting: Private or commercial…

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All Posts
Newsletter March 2021
March 30, 2021

NEWS from the PAASP network          – New series of EQIPD lectures – Read more         …

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A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

Read More
WANTED – Cartoon artist
March 30, 2021

We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…

Read More
Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

Read More