EDUCATIONAL CORNER

A carefully curated collection of news and resources relevant to our favorite topics.

Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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Case Studies
Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Beauty is not everything
May 28, 2020

Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…

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Editorials
PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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eNeuro publishes Series on Scientific Rigor
July 22, 2016

Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…

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An incentive-based approach for improving data reproducibility
April 29, 2016

In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…

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Tools for researchers
What is the optimum design for my animal experiment?
June 16, 2021

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

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The MDAR Framework – a new tool for life sciences reporting
June 16, 2021

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

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EQIPD Quality System published
June 16, 2021

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

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A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

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New Publications
Additional reads in June 2021
June 16, 2021

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

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Putting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

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Creating clear and informative image-based figures for scientific publications
June 16, 2021

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

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What is the optimum design for my animal experiment?
June 16, 2021

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

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Commentaries
How to See More Clearly in the Lab?
June 16, 2021

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

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Aducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

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WANTED – Cartoon artist
March 30, 2021

We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…

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Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

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Fun Section
A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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Fun Section January 2020
February 1, 2020

A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…

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All Posts
Webinar at scientist.com
June 21, 2021

PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…

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Newsletter June 2021
June 16, 2021

NEWS           – New EQIPD paper published – Read more          – The MDAR Framework –…

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A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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How to See More Clearly in the Lab?
June 16, 2021

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

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