EDUCATIONAL CORNER

A carefully curated collection of news and resources relevant to our favorite topics.

Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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Case Studies
In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Beauty is not everything
May 28, 2020

Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…

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Covid-19 and the PPV
May 28, 2020

There has been a lot in the news recently about using antibody tests to detect people who have had Covid-19 and…

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Editorials
PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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eNeuro publishes Series on Scientific Rigor
July 22, 2016

Christophe Bernard, editor in chief of eNeuro, mentions in this editorial the issue of scientific rigor with a reference to two Commentaries…

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An incentive-based approach for improving data reproducibility
April 29, 2016

In the editorial published in Science Translational Medicine, Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results…

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Tools for researchers
How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Successful adaption of the EQIPD Quality System to specific research needs
December 18, 2020

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

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Ten simple rules on how to write a standard operating procedure
October 8, 2020

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

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EQIPD: PAASP’s contribution to the new Quality System for preclinical research
October 8, 2020

EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…

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New Publications
ADDITIONAL READS IN DECEMBER 2020
December 18, 2020

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

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How often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

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Publication rate in preclinical research: a plea for preregistration
December 18, 2020

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

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Use of causal claims in observational studies: a research on research study
December 18, 2020

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

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Commentaries
Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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A time to cast away stones, and a time to gather stones together
December 18, 2020

Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…

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Violation of research integrity by selective citation
October 8, 2020

We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…

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Fun Section
Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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Fun Section January 2020
February 1, 2020

A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…

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Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
December 18, 2019

Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.Design: Randomized controlled trial.Setting: Private or commercial…

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All Posts
Newsletter December 2020
December 18, 2020

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

Read More
Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

Read More
The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

Read More