Further commentaries, articles and blog posts worth reading:Zen und die Kunst, Forschung zu bewerten (in German)  In defense of quantitative metrics…

This is one of the first publications reporting the results of original research performed in an EQIPD-certified laboratory. This study was…

The influence of protocol standardization between laboratories on their replicability of preclinical results has not been addressed in a systematic way….

In many fields of biomedical research, in vivo studies traditionally involved the use of male subjects.  The situation recently started to…

Further commentaries, articles and blog posts worth reading: Without appropriate metadata, data-sharing mandates are pointless Research funders and the promotion of…

Most discussions of reliability problems in science focus on systematic biases. In this article, Nate Breznau and colleagues broaden the lens…

Destroying image integrity in scientific papers may result in serious consequences. Inappropriate duplication and fabrication of images are two common misconducts…

Citation data and journal impact factors are important components of faculty dossiers and figure prominently in both promotion decisions and assessments…

The objective of the study was to analyze researchers’ compliance with their data availability statement (DAS) from manuscripts published in open-access…

In this article, Jean-Antoine Girault proposed a simple change in the way scientists publish their findings to improve reliability and reproducibility…

The EQIPD framework for rigor in the design, conduct, analysis, and documentation of animal experiments was published today. It defines the demands for…

European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done?  ‘Robot scientist’…

Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…

In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

In light of the reproducibility crisis, there is a growing awareness that the rigorous standardization of experimental conditions may contribute to…

Scientific results should be reproducible and robust. However, when reproducibility is tested, it is often not found (often termed ’reproducibility crisis’),…

Systematic reviews and meta-analyses deliver a crystallized understanding of the existing research data in any given space. However, grappling with the…

Ensuring reproducibility and replicability has been an issue in many scientific disciplines in the past decade. In this commentary, Matthew Faria…

Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…

In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…

The new normal? Redaction bias in biomedical science Why Discovering ‘Nothing’ in Science Can Be So Incredibly Important New Frontiers research…

Research focusing on epigenetic modifications is a growing field in the neuroscience area. However, issues related to data reproducibility across laboratories…

Registered Reports are a form of publication in which study proposals are peer reviewed and pre-accepted before research is undertaken. By deciding which…

A spectre is haunting biomedical research: It appears that a substantial fraction of published research results cannot be reproduced, while spectacularly…

Want research integrity? Stop the blame game Einstein Foundation Award 2021 Understand the real reasons reproducibility reform fails Five keys to…

In this article, Marta Serra-Garcia and Uri Gneezy used publicly available data to show that published papers in top psychology, economics,…

Replicability is an important feature of scientific research. Thus, the Reproducibility Project: Cancer Biology was set up to provide evidence about…

Some journals have implemented guidelines regarding the use and reporting of cell lines, antibodies, and laboratory animals to improve the value…

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical…

Registered Reports are a form of empirical publication in which study proposals are peer reviewed and pre-accepted before research is undertaken….

Science Forum: A community-led initiative for training in reproducible research Reproducibility: expect less of the scientific paper Share methods through visual…

Although the issues related to poor quality of medical research are well known, the research community fails to properly address them….

With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…

In registered reports (RRs), initial peer review and in-principle acceptance occur before knowing the research outcomes. This combats publication bias and…

Preclinical systematic reviews are vital; they serve many purposes by assessing the range and quality of the evidence. Through these reviews…

Together with the group of Ulf Kahlert from the University of Düsseldorf, PAASP’s Björn Gerlach published an article in F1000Research on…

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…

While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…

PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…

Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…

For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…

SuperPlots: Communicating reproducibility and variability in cell biology Against pandemic research exceptionalism Pseudoscience and COVID-19 — we’ve had enough already Spin…

Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…

Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…

PLOS has launched a major survey targeting researchers in North America and Europe: The goal is to deepen the understanding of…

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…

To test the reproducibility and robustness of results obtained in the neuroimaging field, 70 independent teams of neuroimaging experts from across…

Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…

Preregistration of exploratory research: Learning from the golden age of discovery What Research Institutions Can Do to Foster Research Integrity When…

Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…

There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue,…

The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…

There is an ongoing debate regarding the robustness and credibility of published scientific research. In this article, the authors argue that…

Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of irreproducibility….

Like everyone else we are with a great concern given the current coronavirus situation and the beginning of a global experiment:…

Measuring Transparency and Reproducibility of Biomedical Articles Causal claims about correlations reduced in press releases following academic study of health news…

After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…

Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved…

The reproducibility crisis in science is a multifaceted problem involving practices and incentives, both in the laboratory and in publication.Using SciScore,…

To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…

Why scientists need to be better at data visualization Statistical significance gives bias a free pass Petitions in scientific argumentation: Dissecting…

Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…

Non-publication and publication bias in animal research are prominent topics in current debates on the “reproducibility crisis” and “failure rates in…

PAASP’s Anton Bespalov together with Phil Skolnick (Opiant) and Thomas Steckler (Janssen) address the issue of negative data being rarely disclosed…

Fixing the Flaws in Animal Research No Crisis but No Time for Complacency Licence to publish will restore trust in science…

Use of high-quality tools is an essential element of Good Research Practice. Like for many other aspects, “high quality” is a…

The objective of this study by Rauh et al. was to evaluate the nature and extent of reproducible and transparent research…

A range of problems currently undermines public trust in biomedical research. In this article, Mark Yarborough and colleagues discuss four erroneous…

Mice can be a valuable model for early biomedical research, but many of the drugs that demonstrate promising results in these…