EDUCATIONAL CORNER

Guidelines in Research
PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
May 28, 2020

Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…

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Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative
March 31, 2020

The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…

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New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
February 1, 2020

To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…

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A consensus-based transparency checklist
December 18, 2019

Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…

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ARRIVE 2.0
November 22, 2019

A long-awaited revision of the ARRIVE guidelines has finally been published (The ARRIVE guidelines 2019).What impact can we expect from ARRIVE…

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Toward Good In Vitro Reporting Standards
November 22, 2019

Many areas of biomedical science have developed reporting standards and checklists to support the adequate reporting of scientific efforts, but in…

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New Handbook of Experimental Pharmacology focusing on Good Research Practice
November 22, 2019

The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and…

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Good Practice for Conference Abstracts and Presentations: GPCAP
August 12, 2019

GPCAP provides recommendations on good submission and presentation practice for scientific and medical congresses. These recommendations cover conference abstracts, posters and…

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Willing to test ARRIVE guidelines?
August 12, 2019

The NC3R is looking for volunteers to test and share experience about the newly published ARRIVE guidelines. Testing newly developed guidelines…

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Updated Arrive guidelines 2019
July 18, 2019

A long awaited revision of the ARRIVE guidelines has finally been published. There are three main reasons why the revision was…

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To Have Practical Relevance, Scientific Claims Need to be Accurate
September 10, 2018

For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is…

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Guidelines on statistics for researchers using laboratory animals: the essentials
September 10, 2018

There is a growing concern that flawed statistics and deficient reproducibility in biomedical studies results in an unethical waste of animals…

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A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)
September 10, 2018

The ARRIVE guidelines are widely endorsed but compliance is limited. The IICARus Collaboration group sought to determine whether journal-requested completion of…

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Unambiguous identification of antibodies, cell lines and organisms around the globe: A call for the Research Resource ID
August 21, 2018

Unambiguous identification of antibodies, cell lines and organisms around the globe: A call for the Research Resource ID The reproducibility crisis…

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FAIR and ALCOAplus – data management principles
August 13, 2018

Data recording practices play a central element in research and can vary largely from lab to lab and researcher to researcher….

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Newly developed ‘Harmonized animal research reporting principles’ (HARRP) published
July 9, 2018

The International Council for Laboratory Animal Science (ICLAS) has recently published Harmonized Animal Research Reporting Principles (HARRP), the first step of…

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Improving animal research reporting standards
June 6, 2018

For decades, scientists and organizations have expressed concerns about the quality of animal research reporting. These concerns and efforts to establish…

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PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) Guidelines
March 30, 2018

As part of ongoing efforts to reduce waste and increase the reproducibility of animal research and testing, a group of experts…

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PREPARE: guidelines for planning animal research and testing
February 26, 2018

The PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) guidelines were published in 2017 to provide overarching guidance on…

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Study Design
August 17, 2017

These articles are presenting ideas on how to improve experiments. Howells, DW et al. 2014. “Bringing rigour to translational medicine.” Nature…

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“The TOP Guidelines”
July 21, 2017

Guidelines for Transparency and Openness Promotion (TOP) in Journal Policies and Practices which are published by the Center for Open Science…

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Nosek et al., 2015 Science
July 21, 2017

Brian Nosek et al. present in this communication an informative introduction to standards set-up by the Transparency and Openness Promotion (TOP)…

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The Committee on Publication Ethics (COPE)
July 21, 2017

The Committee on Publication Ethics was established in 1997 and has grown to over 10000 members. It provides advice on publication…

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RIGOR guidelines
July 21, 2017

Comprehensive guidelines especially designed for research in animal models of stroke. However, it does contain basic aspects that can be applied…

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MIFlowCyt guidelines
July 21, 2017

Lee et al., 2008 Journal of the International Society for Advancement of Cytometry (“MIFlowCyt”) Guidelines about the Minimum Information a Flow…

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Steckler et al. 2016 editorial in psychopharmacology
July 21, 2017

These recently published guidelines for the Journal of Psychopharmacology are a great example on information to be reported with animal experiments.

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Simera et al., 2010 Eur J of Clin Invest
July 21, 2017

Introduction to the EQUATOR Network, which provides resources, education and training to facilitate good research reporting and assists in the development,…

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Bravo et al., 2015 BMC Medicine
July 21, 2017

Guideline on how to cite bioresources (CoBRA). LINK

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Moher et al., 2015 BMC Medicine
July 21, 2017

Overview of published guidelines on reporting preclinical research. LINK

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Ioannidis and Khoury, 2014 JAMA
July 21, 2017

In this viewpoint the assessing value in biomedical research is discussed based on research that is Productive, High-quality, Reproducible, Shareable and…

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Guidelines by the European Science Foundation (ESF)
July 21, 2017

The European Code of Conduct for Research Integrity Intended to provide an europe-wide reference, this code addresses  the proper conduct and…

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Steward and Balice-Gordon, 2014 Neuron
July 21, 2017

Review of best practices and presentation of new guidelines with a focus on preclinical studies relevant to human neurological and psychiatric…

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WHO quality practices
July 21, 2017

The WHO provides in this handbook guidance for research institutions and individual researchers to improve the quality of their research data….

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GSP document by DFG
July 21, 2017

Proposal for Safeguarding Good Scientific Practice by the German Research Foundation (DFG). The first recommendations were published in 1997 with an…

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MIATA guidelines
June 26, 2017

This webpage provides useful information on how to publish data derived from flow cytometry experiments in particular when analysing T-cells and…

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STROBE Statement
June 26, 2017

“STROBE stands for an international, collaborative initiative of epidemiologists, methodologists, statisticians, researchers and journal editors involved in the conduct and dissemination…

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ARRIVE guidelines 2010
June 26, 2017

NEW guidelines are available: Updated Arrive guidelines These guidelines were presented by the National Centre for the Replacement, Refinement and Reduction of…

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Are ‘Secret’ Software Codes part of the reproducibility crisis?
June 7, 2017

A commentary based on the two articles by Jiménez et al. and Eglen et al. about the need to publish the…

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Webinar: ‘GRADE for preclinical animal studies: translating evidence from bench to bedside’
May 19, 2017

Laboratory animal studies are used in a wide range of human health related research areas. The results of these studies can…

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A STAR Is Born
August 25, 2016

A STAR Is Born – Cell Press transforms the methods section of articles to improved transparency and accessibility. As one of the…

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