EDUCATIONAL CORNER

Commentaries
Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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A time to cast away stones, and a time to gather stones together
December 18, 2020

Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…

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Violation of research integrity by selective citation
October 8, 2020

We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…

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Federal judge invalidates patents – but on the basis of a common statistical mistake
August 17, 2020

In a recent case before the US District Court in the District of Nevada, the judge ruled six method-of-use patents to…

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Our study was conducted according to…
August 17, 2020

Our stu Over the past several years, more and more journals have revised their guides for authors and included specific instructions…

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The Embassy of Good Science – An online platform fostering research integrity
March 31, 2020

By Iris Lechner The field of research integrity is growing substantially. An increasing number of guidelines and initiatives to foster responsible research…

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Commentary March 2020
March 31, 2020

Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…

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Improving quality of preclinical academic research through auditing: A feasibility study
March 31, 2020

Commentary provided by Claudia Kurreck (Department of Experimental Neurology, Charité -Universitätsmedizin Berlin, Germany) The performance of audits and assessments is always a…

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Of lab notebooks and leaders in science
February 1, 2020

Good research practices are often said to work against the current success model in science (based on positive results, number and…

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Is N-Hacking ever OK?
February 1, 2020

It has been proposed repeatedly that adding samples based on results of initial experiments is a form of p-hacking (see e.g. new…

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Instead of replicating studies with problems, let’s replicate the good studies
December 18, 2019

A few months ago, the “Reproducibility and Replicability in Science” report from the National Academies of Sciences, Engineering, and Medicine was…

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An ounce of prevention is worth a pound of cure
December 18, 2019

We have read with great interest a recent commentary in Nature about scientific research organizations hiring integrity reviewers to vet their manuscripts before…

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ARRIVE 2.0
November 22, 2019

A long-awaited revision of the ARRIVE guidelines has finally been published (The ARRIVE guidelines 2019).What impact can we expect from ARRIVE…

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“Avoiding the Edge Effect – How to increase reproducibility of in vitro microplate experiments?”
August 12, 2019

The randomization of study subjects is commonly discussed for in vivo studies and is in general an accepted practice. However, for…

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“Integrity and Trust, a University cannot do Without”
August 12, 2019

“Trust us, we are a University”KU Leuven was ranked the most innovative university in Europe for the fourth year in a row! This…

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Invited Commentary: Qeios – from a powerful writing tool to an immidiate Open Access platform
August 12, 2019

By Gabriele MarinelloCo-founder, Qeios We have just started with Qeios the path towards the necessary revolution in research production, quality check and sharing.We…

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MANILA – A web tool for designing reproducible and transparent preclinical intervention studies
May 22, 2019

Teemu D. Laajala1,21: University of Turku, Turku (Finland), Department of Mathematics and Statistics2: University of Colorado, Denver (CO, US), Anschutz Medical…

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Searching for incentives to do better research
May 22, 2019

n a recent commentary, Dorothy Bishop has referred to “the four horsemen of the reproducibility apocalypse: publication bias, low statistical power, P-value…

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It takes two to do the dance
May 22, 2019

We are often asked what is meant by “quality culture”. As one of our colleagues put it, “quality culture is the…

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Trial Transparency at European Universities
May 22, 2019

We have previously discussed that there are significant efforts to make results of all clinical trials public. And there are already…

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Tax support and incentives for research and development
May 22, 2019

In many countries, governments are developing and implementing various mechanisms to incentivize innovative research and development. There is a new mechanism recently announced…

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private forever
May 22, 2019

There is growing awareness about the values of preregistered studies or key elements thereof. And there is a growing number of…

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Promoting transparency in preclinical research: preregistration of animal study protocols on www.preclinicaltrials.eu
March 11, 2019

Smit NW1, Van der Naald M2,3, Wever KE4, Duncker DJ1,5, Chamuleau SAJ2,3,6   1Netherlands Heart Institute, The Netherlands 2University Medical Center Utrecht, The…

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Balancing futility and benefit – Is academic research ready for higher research quality standards?
December 20, 2018

byAnton Bespalov (PAASP)Adrian G. Barnett (Queensland University of Technology, Brisbane, Australia)C. Glenn Begley (BioCurate, Melbourne, Australia) *For a condensed version of this…

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Octopus – a replacement for scientists publishing that rewards good research?”
December 20, 2018

by Dr Alexandra Freeman After 17 years working in the media I have returned to academia and been shocked to discover so…

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Of negative results and dust
November 17, 2018

Do studies with negative results have value or not? We hope that majority of our readers would agree that high-quality results…

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Cutting the Gordian knots of industry-academia relationships
November 17, 2018

Facing a seemingly intractable problem, we are often moved to go for any fast solution – just not to deal with…

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Gods vs Earth Giants
November 17, 2018

by Elena Koustova In the long gone Soviet higher (university-based) education system there were no electives. As aspiring biologists (e.g. natural…

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“Research quality is an urgent matter”
September 10, 2018

In the March 2018 issue of the newsletter, we have previously discussed that the research rigor & reproducibility discussion starts to…

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“How to pick an electronic laboratory notebook?
September 10, 2018

Commentary about the Nature-Toolbox article by Roberta Kwok (August 6th, 2018) Laboratory Notebooks (LN) play a key role in research since…

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Elsevier replies to The Guardian
July 9, 2018

Hot publications appear not only in Science and Nature. The lay press is also capable of getting their readers excited and…

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Before Reproducibility must come Preproducibility
July 9, 2018

Many of us ask a question – what can I do to help improve the research data quality? And we are…

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The strategy may change, but high quality standards should stay
July 9, 2018

Like many of our colleagues in neuroscience, we were surprised to see the recent steps Pfizer took in the field of…

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Is reading book summaries the same as reading the actual book?
June 6, 2018

Books that can be summarized in three sentences (https://jamesclear.com/book-summaries). And one can summarize in a couple of sentences what most movies…

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How to grow a healthy lab
June 6, 2018

A healthy research environment is fundamental to good science. However, this is an aspect that is rarely discussed. That’s partly because…

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How to shift the incentive for researchers from quantity to quality?
June 6, 2018

In the current hyper-competitive research environment, scientists feel the constant need to publish novel findings as often and as fast as…

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Crossing the river
March 30, 2018

In the previous issue of the Newsletter, we have already highlighted the recent paper by Bernhard Voelkl et al. from University…

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Everyone knows mouse research is completely pointless
March 30, 2018

We strongly disagree with the title above – however, this statement is borrowed from a recent post on Medical Republic. While…

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‘Don’t shoot the dog!’
February 27, 2018

Behavioral scientists know very well how to train humans and animals to perform a desired response and how to avoid behaviors…

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Lessons from clinical studies’ (Martin C. Michel)
January 23, 2018

At least partly driven by regulatory requirements, technical data quality in clinical studies has markedly improved in the past decades and…

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The link between Portfolio Evolution and the Robustness of early phase drug discovery data
December 19, 2017

The reproducibility discussion involves everyone who funds, authorizes, supervises, plans, conducts and publishes research. This recent LifeSciVC post showed that lacking…

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‘How many studies produce negative results?’
November 10, 2017

The July issue of the Newsletter mentioned a recent publication by Daniel Benjamin and his colleagues who have analyzed the ability…

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Simple Randomisation
October 11, 2017

A randomization tool for the daily routine The case study in this Newsletter illustrates very well the importance of study subject…

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Block randomisation
October 11, 2017

In this section we provide information about useful tools for designing and analyzing experiments – instruments and equipment, which we at…

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Neuroscience has quietly become a hot space for start-ups
September 28, 2017

The most recent post in the LiveSciVC blog opens with the statement: “Neuroscience has quietly become a hot space for start-ups”. Does this…

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‘Redefine statistical significance’
September 1, 2017

A P-value of < 0.05 is commonly accepted as the borderline between a finding and the empty-handed end of a research…

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Two neglected aspects when discussing research quality
August 23, 2017

Scientific Excellence vs. Research Quality Regulated vs. Non-regulated Scientific excellence is the key to advance science and to develop novel drugs….

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‘German Leibniz Institute director Karl Lenhard Rudolph guilty of misconduct’
August 17, 2017

On June 15th, 2017, The Leibniz Association, one of the largest networks of non-profit research institutions in Germany, has announced a…

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Are ‘Secret’ Software Codes part of the reproducibility crisis?
June 7, 2017

A commentary based on the two articles by Jiménez et al. and Eglen et al. about the need to publish the…

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Not allowed to publish everywhere
March 26, 2017

The Economist reported (link) that the biggest foundation in the world, the Bill & Melinda Gates Foundation, have a new policy…

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The Interplay between Data Quality and Animal Welfare
February 28, 2017

The 3Rs (Replacement, Reduction and Refinement) originating from Russell and Burch (1959) are the guiding principles in preclinical animal research. They…

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Publish or Perish Debate at WCAA
January 30, 2017

Together with Rainer Spanagel (Central Institute of Mental Health, Mannheim) and Henry Kranzler (University of Pennsylvania Perelman School of Medicine), Anton…

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A manifesto for reproducible science
January 11, 2017

Manufo et al published an open access manifesto in Nature Human Behavior for reproducible science. This interesting piece summarizes the problems…

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Ranking major and minor research misbehaviors: results from a survey among participants of four World Conferences on Research Integrity
November 26, 2016

This recently published survey identifies the most frequent problem in science: sloppy research.  The survey was performed among participants of the…

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Preclinical data reproducibility discussion: Learning from Big Brother
October 24, 2016

In recent years, robustness of preclinical data has been increasingly in focus of discussions about the reasons why the success rate…

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Predatory Publishing Threatens the Scientific Enterprise
October 11, 2016

Open-access publishing has grown dramatically, with a linear increase in the number of articles published, from about 53,000 in 2010 to…

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Statement by Martin Michel
September 9, 2016

“In God we trust” is minted on each US coin. The evidence-based medicine movement has adapted this to “In God we…

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Intelligent Effort – Quality in Drug Discovery
July 22, 2016

Guest commentary by Dr. Markus Henrich There is a high demand for quality in daily life. Few of us would actively decide…

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