Additional Reads in November 2021
November 3, 2021Science Forum: A community-led initiative for training in reproducible research Reproducibility: expect less of the scientific paper Share methods through visual…
Read MoreMethodology over metrics: current scientific standards are a disservice to patients and society
November 3, 2021Although the issues related to poor quality of medical research are well known, the research community fails to properly address them….
Read MoreToward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…
Read MoreInitial evidence of research quality of registered reports compared with the standard publishing model
November 3, 2021In registered reports (RRs), initial peer review and in-principle acceptance occur before knowing the research outcomes. This combats publication bias and…
Read MoreTechnological advances in preclinical meta-research
November 3, 2021Preclinical systematic reviews are vital; they serve many purposes by assessing the range and quality of the evidence. Through these reviews…
Read MoreeLabFTW as an Open Science tool to improve the quality and translation of preclinical research
November 3, 2021Together with the group of Ulf Kahlert from the University of Düsseldorf, PAASP’s Björn Gerlach published an article in F1000Research on…
Read MoreAdditional reads in June 2021
June 16, 2021Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…
Read MorePutting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…
Read MoreCreating clear and informative image-based figures for scientific publications
June 16, 2021Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…
Read MoreWhat is the optimum design for my animal experiment?
June 16, 2021Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…
Read MoreMeta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research
June 16, 2021The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…
Read MoreThe MDAR Framework – a new tool for life sciences reporting
June 16, 2021Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…
Read MoreEQIPD Quality System published
June 16, 2021The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…
Read MoreAdditional reads in March 2021
March 30, 2021Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…
Read MoreReactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…
Read MoreTaking a fresh look at FAIR for research software
March 30, 2021Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…
Read MoreAdvancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…
Read MoreReproducible image handling and analysis
March 30, 2021Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…
Read MoreAn excess of positive results: Comparing the standard Psychology literature with Registered Reports
March 30, 2021Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…
Read MoreADDITIONAL READS IN DECEMBER 2020
December 18, 2020Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…
Read MoreHow often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…
Read MorePublication rate in preclinical research: a plea for preregistration
December 18, 2020In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….
Read MoreUse of causal claims in observational studies: a research on research study
December 18, 2020Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…
Read MoreCredibility of preprints: an interdisciplinary survey of researchers
December 18, 2020Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…
Read MoreThe “replication crisis” in the public eye: Germans’ awareness and perceptions of the (ir)reproducibility of scientific research
December 18, 2020While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…
Read MoreNew publication co-authored by PAASP: Survey of Core Facilities shows the importance of communication and management for optimal research quality
December 18, 2020PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…
Read MorePAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreAdditional reads in October 2020
October 8, 2020When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…
Read MoreHow the COVID-19 pandemic highlights the necessity of animal research
October 8, 2020Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…
Read MoreTen simple rules on how to write a standard operating procedure
October 8, 2020The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…
Read MoreReproducibility in systems biology modelling
October 8, 2020The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…
Read MorePAASP Editorial in the Journal Temperature
October 8, 2020Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…
Read MoreReproducibility in systems biology modelling
August 25, 2020A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…
Read MoreRisk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments
August 17, 2020There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…
Read MoreAdditional reads in August 2020
August 17, 2020Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…
Read MoreChoice of y-axis can mislead readers
August 17, 2020Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…
Read MoreUsing Bayes factor hypothesis testing in neuroscience to establish evidence of absence
August 17, 2020For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…
Read MoreAdvancing science or advancing careers? Researchers’ opinions on success indicators
August 17, 2020The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…
Read MoreAcademic criteria for promotion and tenure in biomedical sciences faculties: cross-sectional analysis of international sample of universities
August 17, 2020Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…
Read MoreReproducibility of animal research in light of biological variation
August 17, 2020Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…
Read MoreAdditional reads in May 2020
May 28, 2020SuperPlots: Communicating reproducibility and variability in cell biology Against pandemic research exceptionalism Pseudoscience and COVID-19 — we’ve had enough already Spin…
Read MoreOctopus: The primary research record
May 28, 2020Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…
Read MoreUsing Microsoft OneNote as an ELN
May 28, 2020Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…
Read MorePLOS launches research data survey
May 28, 2020PLOS has launched a major survey targeting researchers in North America and Europe: The goal is to deepen the understanding of…
Read MoreDie Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…
Read MoreSystematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
May 28, 2020Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…
Read MoreVariability in the analysis of a single neuroimaging dataset by many teams
May 28, 2020To test the reproducibility and robustness of results obtained in the neuroimaging field, 70 independent teams of neuroimaging experts from across…
Read MoreCommentary March 2020
March 31, 2020Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…
Read MoreAdditional reads in March 2020
March 31, 2020Preregistration of exploratory research: Learning from the golden age of discovery What Research Institutions Can Do to Foster Research Integrity When…
Read MoreComparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature
March 31, 2020Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…
Read MoreResearch Culture: Framework for advancing rigorous research
March 31, 2020There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue,…
Read MoreImproving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative
March 31, 2020The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…
Read MoreResearch Culture and Reproducibility
March 31, 2020There is an ongoing debate regarding the robustness and credibility of published scientific research. In this article, the authors argue that…
Read MoreNo raw data, no science: another possible source of the reproducibility crisis
March 31, 2020Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of irreproducibility….
Read MoreCoronavirus: The need for solid, robust data
March 31, 2020Like everyone else we are with a great concern given the current coronavirus situation and the beginning of a global experiment:…
Read MoreAdditional READS in January 2020
February 1, 2020Measuring Transparency and Reproducibility of Biomedical Articles Causal claims about correlations reduced in press releases following academic study of health news…
Read MoreIs N-Hacking Ever OK? A simulation-based study
February 1, 2020After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…
Read MorePublishers’ Responsibilities in Promoting Data Quality and Reproducibility
February 1, 2020Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved…
Read MoreRigor and Transparency Index, a new metric of quality for assessing biological and medical science methods.
February 1, 2020The reproducibility crisis in science is a multifaceted problem involving practices and incentives, both in the laboratory and in publication.Using SciScore,…
Read MoreNew Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
February 1, 2020To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…
Read MoreADDITIONAL READS December 2019
December 18, 2019Why scientists need to be better at data visualization Statistical significance gives bias a free pass Petitions in scientific argumentation: Dissecting…
Read MoreA consensus-based transparency checklist
December 18, 2019Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…
Read MorePublication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
December 18, 2019Non-publication and publication bias in animal research are prominent topics in current debates on the “reproducibility crisis” and “failure rates in…
Read MoreBe positive about negatives – recommendations for the publication of negative (or null) results.
December 18, 2019PAASP’s Anton Bespalov together with Phil Skolnick (Opiant) and Thomas Steckler (Janssen) address the issue of negative data being rarely disclosed…
Read MoreAdditional reads November 2019
November 22, 2019Fixing the Flaws in Animal Research No Crisis but No Time for Complacency Licence to publish will restore trust in science…
Read MoreOff-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
November 22, 2019Use of high-quality tools is an essential element of Good Research Practice. Like for many other aspects, “high quality” is a…
Read MoreReproducible and Transparent Research Practices in Published Neurology Research
November 22, 2019The objective of this study by Rauh et al. was to evaluate the nature and extent of reproducible and transparent research…
Read MoreFour erroneous beliefs thwarting more trustworthy research
November 22, 2019A range of problems currently undermines public trust in biomedical research. In this article, Mark Yarborough and colleagues discuss four erroneous…
Read MoreLaboratory mice born to wild mice have natural microbiota and model human immune responses
November 22, 2019Mice can be a valuable model for early biomedical research, but many of the drugs that demonstrate promising results in these…
Read MoreNew Handbook of Experimental Pharmacology focusing on Good Research Practice
November 22, 2019The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and…
Read MoreAdditional reads August 2019
August 12, 2019Road testing ARRIVE 2019 Rethinking impact factors: better ways to judge a journal A Waste of 1,000 Research Papers The p…
Read MoreMeta-Research: Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations
August 12, 2019When issues associated with the current academic evaluation systems are discussed, the use – and potential misuse – of the JIF…
Read MoreOutcome heterogeneity and bias in acute experimental spinal cord injury
August 12, 2019In this meta-analysis and meta-regression, Ralf Watzlawick and colleagues determined the impact of study characteristics, methodologic and reporting bias, and the…
Read MoreGood Practice for Conference Abstracts and Presentations: GPCAP
August 12, 2019GPCAP provides recommendations on good submission and presentation practice for scientific and medical congresses. These recommendations cover conference abstracts, posters and…
Read MoreThe association between quality measures of medical university press releases and their corresponding news stories
August 12, 2019One of the key sources of health-related and medical information are university press releases (PR). This study by Maike Winters et…
Read MoreKnowledge and attitudes among life scientists towards reproducibility within journal articles
August 12, 2019This study by EK Samota and RP Davey investigated the knowledge of researchers about issues related to data reproducibility as well…
Read More3Rs missing: animal research without scientific value is unethical
August 12, 2019The scientists in biomedical research are increasingly worried about the growing number of rules and regulations that they have to comply…
Read MoreFailing Grade: 89% of Introduction-to-Psychology Textbooks That Define or Explain Statistical Significance Do So Incorrectly
August 12, 2019Null-hypothesis significance testing (NHST) is commonly used in psychology and biomedical research areas. However, statisticians have long warned that researchers regularly…
Read MoreA Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines
August 12, 2019In the biomedical field, a significant proportion of preclinical research data sets are not robust enough to translate into successful clinical…
Read MoreUpdated review of electronic laboratory notebooks (ELNs) published by LabsExplorer
May 22, 2019LabsExplorer has recently published an updated review on electronic lab notebooks. The first review was published in 2017 (LINK) giving a…
Read MoreSearching for incentives to do better research
May 22, 2019n a recent commentary, Dorothy Bishop has referred to “the four horsemen of the reproducibility apocalypse: publication bias, low statistical power, P-value…
Read MoreTo “p” or not to “p”
May 22, 2019“A biologist and a statistician are in prison and, before being executed, are asked about their last wish. Statistician wants to…
Read MoreAdditional Read in may 2019
May 22, 2019Unclog pipeline for new medicines Improving the way research is done: the UK Reproducibility Network Major medical journals don’t follow their…
Read MoreFAIRsharing as a community approach to standards, repositories and policies
May 22, 2019We say we need standards, but do we use them?The scientific community, funders and publishers endorse the concept that common data…
Read MoreComparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature
May 22, 2019Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…
Read MoreExact replication: Foundation of science or game of chance?
May 22, 2019The replication of initial results is a critical part of the scientific process. In preclinical biomedical research, it is common practice…
Read MoreEndogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection
May 22, 2019An important source of variation in animal experiments is the microbiome, but little is known about specific changes in the microbiota…
Read MoreReplication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
March 13, 2019The Reproducibility Project: Cancer Biology aims to replicate a number of landmark studies in the field of tumor biology published between 2010 –…
Read MoreAdditional Reads in March 2019
March 11, 2019The reproducibility crisis in the age of digital medicine It’s not a replication crisis. It’s an innovation opportunity The Role of…
Read MoreMeta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines
March 11, 2019Scientific articles using cell lines, which are registered on the International Cell Line Authentication Committee (ICLAC) or the Cellosaurus database as…
Read MoreWhy we need to report more than ’Data were Analyzed by t-tests or ANOVA’
March 11, 2019In this article,Weissgerber et al. present findings suggesting that scientific publications are often lacking sufficient information about the statistical methods used,…
Read MoreA Reaction Norm Perspective on Reproducibility
March 11, 2019When studying living organisms, scientists are faced with inherent biological variation which is distinct from random noise or measurement error and…
Read MoreVisualization of Biomedical Data
March 11, 2019The rapid increase in volume and complexity of biomedical data requires changes in research, communication, and clinical practices. This includes learning…
Read MoreMax Planck Society ends Elsevier subscription
January 2, 2019The Max Planck Society (MPS) is a German research organisation acting in many different research areas and consists of over 14.000…
Read MoreAdditional Reads in December 2018
December 20, 2018Statistical pitfalls of personalized medicine How sure are you of your result? Put a number on it Design preclinical studies for…
Read MoreTo Read More Papers, or to Read Papers Better? A Crucial Point for the Reproducibility Crisis
December 20, 2018To Read More Papers, or to Read Papers Better? A Crucial Point for the Reproducibility Crisis A huge number of new…
Read MoreHow to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation
December 20, 2018Reproducibility in preclinical research may be low because of the high prevalence of biases and of suboptimal research practices (such as…
Read MoreReproducible research practices, transparency, and open access data in the biomedical literature, 2015–2017
December 20, 2018In this article, the authors analysed potential sources of bias in 149 randomly selected biomedical research papers published between 2015 and…
Read MoreDigital tools and services to support research replicability and verifiability
December 20, 2018Digital tools hold promise for improving replicability and verifiability of scientific research. In this paper, the availability and use of such…
Read MoreAdditional Reads in November 2018
November 17, 2018Further commentaries, articles and blog posts worth reading: Meet Octopus, a new vision for scientific publishing Reboot undergraduate courses for reproducibility…
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