Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…

While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…

PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…

Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…

For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…

SuperPlots: Communicating reproducibility and variability in cell biology Against pandemic research exceptionalism Pseudoscience and COVID-19 — we’ve had enough already Spin…

Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…

Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…

PLOS has launched a major survey targeting researchers in North America and Europe: The goal is to deepen the understanding of…

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…

To test the reproducibility and robustness of results obtained in the neuroimaging field, 70 independent teams of neuroimaging experts from across…

Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…

Preregistration of exploratory research: Learning from the golden age of discovery What Research Institutions Can Do to Foster Research Integrity When…

Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…

There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue,…

The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…

There is an ongoing debate regarding the robustness and credibility of published scientific research. In this article, the authors argue that…

Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of irreproducibility….

Like everyone else we are with a great concern given the current coronavirus situation and the beginning of a global experiment:…

Measuring Transparency and Reproducibility of Biomedical Articles Causal claims about correlations reduced in press releases following academic study of health news…

After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…

Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved…

The reproducibility crisis in science is a multifaceted problem involving practices and incentives, both in the laboratory and in publication.Using SciScore,…

To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…

Why scientists need to be better at data visualization Statistical significance gives bias a free pass Petitions in scientific argumentation: Dissecting…

Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…

Non-publication and publication bias in animal research are prominent topics in current debates on the “reproducibility crisis” and “failure rates in…

PAASP’s Anton Bespalov together with Phil Skolnick (Opiant) and Thomas Steckler (Janssen) address the issue of negative data being rarely disclosed…

Fixing the Flaws in Animal Research No Crisis but No Time for Complacency Licence to publish will restore trust in science…

Use of high-quality tools is an essential element of Good Research Practice. Like for many other aspects, “high quality” is a…

The objective of this study by Rauh et al. was to evaluate the nature and extent of reproducible and transparent research…

A range of problems currently undermines public trust in biomedical research. In this article, Mark Yarborough and colleagues discuss four erroneous…

Mice can be a valuable model for early biomedical research, but many of the drugs that demonstrate promising results in these…

The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and…

Road testing ARRIVE 2019 Rethinking impact factors: better ways to judge a journal A Waste of 1,000 Research Papers The p…

When issues associated with the current academic evaluation systems are discussed, the use – and potential misuse – of the JIF…

In this meta-analysis and meta-regression, Ralf Watzlawick and colleagues determined the impact of study characteristics, methodologic and reporting bias, and the…

GPCAP provides recommendations on good submission and presentation practice for scientific and medical congresses. These recommendations cover conference abstracts, posters and…

One of the key sources of health-related and medical information are university press releases (PR). This study by Maike Winters et…

This study by EK Samota and RP Davey investigated the knowledge of researchers about issues related to data reproducibility as well…

The scientists in biomedical research are increasingly worried about the growing number of rules and regulations that they have to comply…

Null-hypothesis significance testing (NHST) is commonly used in psychology and biomedical research areas. However, statisticians have long warned that researchers regularly…

In the biomedical field, a significant proportion of preclinical research data sets are not robust enough to translate into successful clinical…

LabsExplorer has recently published an updated review on electronic lab notebooks. The first review was published in 2017 (LINK) giving a…

n a recent commentary, Dorothy Bishop has referred to “the four horsemen of the reproducibility apocalypse: publication bias, low statistical power, P-value…

“A biologist and a statistician are in prison and, before being executed, are asked about their last wish. Statistician wants to…

Unclog pipeline for new medicines Improving the way research is done: the UK Reproducibility Network Major medical journals don’t follow their…

We say we need standards, but do we use them?The scientific community, funders and publishers endorse the concept that common data…

Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…

The replication of initial results is a critical part of the scientific process. In preclinical biomedical research, it is common practice…

An important source of variation in animal experiments is the microbiome, but little is known about specific changes in the microbiota…

The Reproducibility Project: Cancer Biology aims to replicate a number of landmark studies in the field of tumor biology published between 2010 –…

The reproducibility crisis in the age of digital medicine It’s not a replication crisis. It’s an innovation opportunity The Role of…

Scientific articles using cell lines, which are registered on the International Cell Line Authentication Committee (ICLAC) or the Cellosaurus database as…

In this article,Weissgerber et al. present findings suggesting that scientific publications are often lacking sufficient information about the statistical methods used,…

When studying living organisms, scientists are faced with inherent biological variation which is distinct from random noise or measurement error and…

The rapid increase in volume and complexity of biomedical data requires changes in research, communication, and clinical practices. This includes learning…

The Max Planck Society (MPS) is a German research organisation acting in many different research areas and consists of over 14.000…

Statistical pitfalls of personalized medicine How sure are you of your result? Put a number on it Design preclinical studies for…

To Read More Papers, or to Read Papers Better? A Crucial Point for the Reproducibility Crisis  A huge number of new…

Reproducibility in preclinical research may be low because of the high prevalence of biases and of suboptimal research practices (such as…

In this article, the authors analysed potential sources of bias in 149 randomly selected biomedical research papers published between 2015 and…

Digital tools hold promise for improving replicability and verifiability of scientific research. In this paper, the availability and use of such…

Further commentaries, articles and blog posts worth reading: Meet Octopus, a new vision for scientific publishing Reboot undergraduate courses for reproducibility…

In this article, 29 independent research teams used the same data set to address the same research question: whether soccer referees…

While L-DOPA remines the gold standard symptomatic treatment for Parkinson’s disease (PD), its long-term use is often associated with motor fluctuations…

Today, the probability of successfully publishing negative/null results in biomedical research is lower than that for positive results. For instance, negative…

In well designed and adequately powered experiments null findings are often as informative as ‘positive’ results but the current incentive structure…

As part of the Reproducibility Project: Cancer Biology, this report describes the attempt to replicate critical experiments from the paper “Intestinal…

In this report, Wang and colleagues present the results of a national survey of nearly 400 consulting statisticians about requests from…

At the presentation of the ECNP Negative Data Award (see above), there was an interesting point made by one of the…

In the March 2018 issue of the newsletter, we have previously discussed that the research rigor & reproducibility discussion starts to…

Commentary about the Nature-Toolbox article by Roberta Kwok (August 6th, 2018) Laboratory Notebooks (LN) play a key role in research since…

“Cluster Failure”: fMRI False Positives Revisited Journals and refereeing: toward a new equilibrium In the name of reproducibility There is an…

In this paper, published in Nature, the authors analysed how different cancer cells are – not so much from the original…

For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is…

There is a growing concern that flawed statistics and deficient reproducibility in biomedical studies results in an unethical waste of animals…