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The EQIPD Quality System was presented at the World Conference on Research Integrity
June 16, 2022

The World Conference on Research Integrity in 2022 happened in Cape Town, South Africa from May 29 to June 01. The…

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First International Society for Preclinical Research Quality Systems Launched
June 16, 2022

The Guarantors of EQIPD e.V. (GoEQIPD) announce the formation of a registered association, registered in Heidelberg Germany, to host and to ensure…

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EQIPD-PAASP working relationship
June 16, 2022

As an important step forward in the evolution of the EQIPD quality system for preclinical research, the Guarantors of EQIPD and the PAASP Network are…

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Newsletter June 2022
June 16, 2022

News First International Society for Preclinical Research Quality Systems Launched – Read more EQIPD-PAASP working relationship – Read more  The EQIPD…

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“Blinding in histopathology assessments – I see your point but…”
June 16, 2022

We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…

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Archimedes‘ fulcrum and the “reproducibility” debate
June 16, 2022

We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…

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“Serial de-risking”: Quod licet Iovi non licet bovi?
June 16, 2022

When it comes to novel therapies, positive data has justifiably more value than negative or null data.  Indeed, positive data promises…

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Additional reads in June 2022
June 16, 2022

European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done?  ‘Robot scientist’…

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Considerations for implementing electronic laboratory notebooks in an academic research environment
June 16, 2022

Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…

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Many researchers were not compliant with their published data sharing statement: mixed-methods stud
June 16, 2022

In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…

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Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
June 16, 2022

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

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Do multiple experimenters improve the reproducibility of animal studies?
June 16, 2022

In light of the reproducibility crisis, there is a growing awareness that the rigorous standardization of experimental conditions may contribute to…

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Testing the reproducibility and robustness of the cancer biology literature by robot
June 16, 2022

Scientific results should be reproducible and robust. However, when reproducibility is tested, it is often not found (often termed ’reproducibility crisis’),…

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What has preclinical systematic review ever done for us?
June 16, 2022

Systematic reviews and meta-analyses deliver a crystallized understanding of the existing research data in any given space. However, grappling with the…

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Reanalysis: the forgotten sibling of reproducibility and replicability
June 16, 2022

Ensuring reproducibility and replicability has been an issue in many scientific disciplines in the past decade. In this commentary, Matthew Faria…

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Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu
June 16, 2022

Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…

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Bringing microscopy images to the next level
June 16, 2022

In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…

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Partnership with GoEQIPD
May 27, 2022

The Guarantors of EQIPD and PAASP Network are delighted to announce the launch of a joint effort to promote the EQIPD framework, to…

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How much power should my next study have: One size fits all?
March 14, 2022

There is a slow but steady increase in the number of publications where authors report on sample size justification.  In most…

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Pre-study odds
March 14, 2022

One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…

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Additional reads in March 2022
March 14, 2022

The new normal? Redaction bias in biomedical science Why Discovering ‘Nothing’ in Science Can Be So Incredibly Important New Frontiers research…

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The MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences
March 14, 2022

The MDAR working group came together in late 2017 with the intention to develop a framework to promote transparent reporting, with…

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The impact of methodology on the reproducibility and rigor of DNA methylation data
March 14, 2022

Research focusing on epigenetic modifications is a growing field in the neuroscience area. However, issues related to data reproducibility across laboratories…

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The past, present and future of Registered Reports
March 14, 2022

Registered Reports are a form of publication in which study proposals are peer reviewed and pre-accepted before research is undertaken. By deciding which…

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External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect
March 14, 2022

A spectre is haunting biomedical research: It appears that a substantial fraction of published research results cannot be reproduced, while spectacularly…

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Newsletter March 2022
March 14, 2022

A snake, having made his hole close to the porch of a cottage, inflicted a severe bite on the cottager’s infant…

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Illustrating the role of PPV, power and sample size with an R script
March 8, 2022

This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott

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Preparing for a journey
February 27, 2022

Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…

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Experiences with the EQIPD QS
January 20, 2022

The perks of a quality system in academia The research group of Prof Kas at the University of Groningen was one…

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NEWSLETTER December 2021
December 20, 2021

EQIPD News Update EQIPD Toolbox: Item “1.4.3.5 Expectations from public funders” – Read more New EQIPD-certified research unit – Read more…

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Reference Collection to push back against “Common Statistical Myths”
December 20, 2021

In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…

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The “from-quality-to-system” pendulum
December 20, 2021

by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…

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Additional Reads in December 2021
December 20, 2021

Want research integrity? Stop the blame game Einstein Foundation Award 2021 Understand the real reasons reproducibility reform fails Five keys to…

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Nonreplicable publications are cited more than replicable ones
December 20, 2021

In this article, Marta Serra-Garcia and Uri Gneezy used publicly available data to show that published papers in top psychology, economics,…

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Investigating the replicability of preclinical cancer biology
December 20, 2021

Replicability is an important feature of scientific research. Thus, the Reproducibility Project: Cancer Biology was set up to provide evidence about…

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Misidentified biomedical resources: Journal guidelines are not a quick fix
December 20, 2021

Some journals have implemented guidelines regarding the use and reporting of cell lines, antibodies, and laboratory animals to improve the value…

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Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases
December 20, 2021

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical…

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The past, present and future of Registered Reports
December 20, 2021

Registered Reports are a form of empirical publication in which study proposals are peer reviewed and pre-accepted before research is undertaken….

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How can Core Facilities support best research practices?
December 20, 2021

Core Facilities (CFs) are a major player within the research landscape since they provide essential infrastructures, experimental support and knowledge to…

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Workshop: “Rigor, reproducibility and data management in nonclinical research”
December 20, 2021

The aim of this workshop was to give participants theoretical knowledge and practical insights into the factors that contribute to poor research…

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New EQIPD-certified research unit
December 20, 2021

Concluding the pilot implementation efforts initiated by the EQIPD consortium team, the Department of Behavioral Neuroscience and Drug Development at the Maj Institute…

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EQIPD Toolbox – Item “1.4.3.5 Expectations from public funders”
December 20, 2021

EQIPD has developed a tool to support a) funders willing to communicate their expectations about data management and rigor in study…

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Support by artificial intelligence
November 3, 2021

https://xkcd.com/2494/ Read More
A wiki platform to support the organization of research labs
November 3, 2021

As part of the PREMIER project, a document sharing system was developed and made freely available as a template to all interested parties…

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NINDS Rigor Resources
November 3, 2021

The National Institute on Neurological Disorders and Stroke (NINDS) has been gathering a list of currently available public resources that are, or can…

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Of peer review and data sharing
November 3, 2021

 We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…

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“Don’t cut the tree you are sitting on!”
November 3, 2021

According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…

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Additional Reads in November 2021
November 3, 2021

Science Forum: A community-led initiative for training in reproducible research Reproducibility: expect less of the scientific paper Share methods through visual…

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Methodology over metrics: current scientific standards are a disservice to patients and society
November 3, 2021

Although the issues related to poor quality of medical research are well known, the research community fails to properly address them….

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Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021

With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…

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Initial evidence of research quality of registered reports compared with the standard publishing model
November 3, 2021

In registered reports (RRs), initial peer review and in-principle acceptance occur before knowing the research outcomes. This combats publication bias and…

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Technological advances in preclinical meta-research
November 3, 2021

Preclinical systematic reviews are vital; they serve many purposes by assessing the range and quality of the evidence. Through these reviews…

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eLabFTW as an Open Science tool to improve the quality and translation of preclinical research
November 3, 2021

Together with the group of Ulf Kahlert from the University of Düsseldorf, PAASP’s Björn Gerlach published an article in F1000Research on…

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PEERS – An Open Science “Platform for the Exchange of Experimental Research Standards” in Biomedicine
November 3, 2021

Do I need to consider the sex of the animals for my study? Is the background noise level likely to vary?…

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Materials Design Analysis Reporting (MDAR) Reports via SciScore
November 3, 2021

We have recently introduced the Materials, Design, Analysis, and Reporting (MDAR) framework aiming at helping authors, editors, and other interested parties to increase…

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UKRN: Open research primers
November 3, 2021

The UK Reproducibility Network (UKRN) has designed a new ‘primer series’ to introduce important topics in open and reproducible scholarship.Each primer…

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Meeting Report: Virtual FENS Regional Meeting 2021
November 3, 2021

On 25 August 2021, at the Virtual FENS Regional Meeting, Anton Bespalov and Malgorzata Pietraszek (PAASP) moderated the Special Interest Event…

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EATRIS Workshop on “Research Quality and Reproducibility”
November 3, 2021

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

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The first EQIPD-certified Research Units:
November 3, 2021

Concluding the pilot implementation efforts initiated by the EQIPD consortium team, the first four Research Units have implemented the EQIPD Quality…

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EQIPD Toolbox
November 3, 2021

We have made substantial updates to the following EQIPD Toolbox items: 1.4.3.3 Academia-academia: Research as service: The recommendations outlined here are…

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EQIPD News on webpage
November 3, 2021

Besides this Newsletter, you will also find all relevant news and developments related to EQIPD on the eqipd.online website and in the EQIPD Toolbox….

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Newsletter November 2021
November 3, 2021

NEWS  EQIPD news News on website – Read more Update on EQIPD Toolbox – Read more EQIPD-certified research units – Read more Workshop on…

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How to SOP
October 25, 2021

Writing Standard Operating Procedures (SOP) is a usual procedure for any organization with a quality manage system. However, also an increasing…

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ERIC forum reports on “Research Quality and Reproducibility Workshop”
October 21, 2021

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

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Webinar at scientist.com
June 21, 2021

PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…

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Newsletter June 2021
June 16, 2021

NEWS           – New EQIPD paper published – Read more          – The MDAR Framework –…

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A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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How to See More Clearly in the Lab?
June 16, 2021

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

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Aducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

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Additional reads in June 2021
June 16, 2021

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

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Putting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

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Creating clear and informative image-based figures for scientific publications
June 16, 2021

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

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What is the optimum design for my animal experiment?
June 16, 2021

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

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Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research
June 16, 2021

The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…

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Standardized and reproducible measurement of decision-making in mice
June 16, 2021

Reproducibility of data has never been more at the forefront of scientific endeavour than now. In their latest contribution, the International…

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The EQIPD Workshop “Rigor, reproducibility and data management in nonclinical research”
June 16, 2021

On 21 April 2021 a virtual EQIPD workshop entitled “Rigor, reproducibility and data management in nonclinical research” was organized in Finland…

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Royal Society Open Science welcomes PCI Registered Reports
June 16, 2021

The Royal Society Open Science is promoting Registered Reports (RRs) by welcoming the submission of Stage 2 Registered Reports that have been…

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The EQIPD principles
June 16, 2021

The EQIPD Toolbox now contains a set of principles, which may help scientists, stakeholders and users to better understand what the…

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The MDAR Framework – a new tool for life sciences reporting
June 16, 2021

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

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EQIPD Quality System published
June 16, 2021

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

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Newsletter March 2021
March 30, 2021

NEWS from the PAASP network          – New series of EQIPD lectures – Read more         …

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A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

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Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

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Let’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021

by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…

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Additional reads in March 2021
March 30, 2021

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

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Reactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

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Taking a fresh look at FAIR for research software
March 30, 2021

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Reproducible image handling and analysis
March 30, 2021

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

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An excess of positive results: Comparing the standard Psychology literature with Registered Reports
March 30, 2021

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

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PREMOS – a new collaboration project involving EQIPD
March 30, 2021

In 2018, the EU has launched the European Brain Research Area (EBRA) project – a catalysing platform designed to coordinate brain…

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Presentation at the BioRN Lounge by Martin Michel
March 30, 2021

PAASP is a member of the science and industry cluster BioRN focusing on the Rhein-Neckar area. The cluster has a get-together with…

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EQIPD helps to define quality expectations for Industry-Academia collaborations
March 30, 2021

Sandrine Bongiovanni and Mathias Baumann (Novartis), Fiona Ducrey (Sanofi), Thomas Steckler and Anja Gilis (Janssen), Anton Bespalov (PAASP), Lee Monk (UCB),…

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New series of EQIPD lectures
March 30, 2021

EQIPD has prepared and recorded a series of lectures introducing its novel Quality System. In these presentations, project coordinator Professor Malcolm Macleod provides…

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Negative Data Award 2021
March 16, 2021

Cohen Veterans Bioscience and ECNP announced on March 8th the “Negative Data Award 2021. Applicants are asked to submit a published…

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Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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Newsletter December 2020
December 18, 2020

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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