The World Conference on Research Integrity in 2022 happened in Cape Town, South Africa from May 29 to June 01. The…

The Guarantors of EQIPD e.V. (GoEQIPD) announce the formation of a registered association, registered in Heidelberg Germany, to host and to ensure…

As an important step forward in the evolution of the EQIPD quality system for preclinical research, the Guarantors of EQIPD and the PAASP Network are…

News First International Society for Preclinical Research Quality Systems Launched – Read more EQIPD-PAASP working relationship – Read more  The EQIPD…

We strongly believe that, in most cases, preclinical in vivo studies conducted without adequate protection against risks of bias (i.e., underpowered, without randomization, blinding,…

We like to cite Dorothy Bishop who wrote several years ago: “We know how to formulate and test hypotheses in controlled…

When it comes to novel therapies, positive data has justifiably more value than negative or null data.  Indeed, positive data promises…

European Journal of Behavior Analysis: women, men, and authorship Are there any good experiments that should not be done?  ‘Robot scientist’…

Stuart Higgins and colleagues describe in this review article the use of electronic laboratory notebooks (ELN) from different perspectives. First, they…

In this article, the authors analysed researchers’ compliance with their Data Availability Statement (DAS) from manuscripts published in open access journals…

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

In light of the reproducibility crisis, there is a growing awareness that the rigorous standardization of experimental conditions may contribute to…

Scientific results should be reproducible and robust. However, when reproducibility is tested, it is often not found (often termed ’reproducibility crisis’),…

Systematic reviews and meta-analyses deliver a crystallized understanding of the existing research data in any given space. However, grappling with the…

Ensuring reproducibility and replicability has been an issue in many scientific disciplines in the past decade. In this commentary, Matthew Faria…

Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…

In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…

The Guarantors of EQIPD and PAASP Network are delighted to announce the launch of a joint effort to promote the EQIPD framework, to…

There is a slow but steady increase in the number of publications where authors report on sample size justification.  In most…

One of the key themes in the 2005 seminal paper by John Ioannidis “Why most published research findings are false” is…

The new normal? Redaction bias in biomedical science Why Discovering ‘Nothing’ in Science Can Be So Incredibly Important New Frontiers research…

The MDAR working group came together in late 2017 with the intention to develop a framework to promote transparent reporting, with…

Research focusing on epigenetic modifications is a growing field in the neuroscience area. However, issues related to data reproducibility across laboratories…

Registered Reports are a form of publication in which study proposals are peer reviewed and pre-accepted before research is undertaken. By deciding which…

A spectre is haunting biomedical research: It appears that a substantial fraction of published research results cannot be reproduced, while spectacularly…

A snake, having made his hole close to the porch of a cottage, inflicted a severe bite on the cottager’s infant…

This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott

Recently, I went on a trip to a nice hotel with a swimming pool. Upon arrival, standing in the modern room…

The perks of a quality system in academia The research group of Prof Kas at the University of Groningen was one…

EQIPD News Update EQIPD Toolbox: Item “1.4.3.5 Expectations from public funders” – Read more New EQIPD-certified research unit – Read more…

In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…

by Anton Bespalov and Anja Gilis In the dialectics world of the German philosopher Georg Hegel, quantitative changes transform into qualitative…

Want research integrity? Stop the blame game Einstein Foundation Award 2021 Understand the real reasons reproducibility reform fails Five keys to…

In this article, Marta Serra-Garcia and Uri Gneezy used publicly available data to show that published papers in top psychology, economics,…

Replicability is an important feature of scientific research. Thus, the Reproducibility Project: Cancer Biology was set up to provide evidence about…

Some journals have implemented guidelines regarding the use and reporting of cell lines, antibodies, and laboratory animals to improve the value…

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical…

Registered Reports are a form of empirical publication in which study proposals are peer reviewed and pre-accepted before research is undertaken….

Core Facilities (CFs) are a major player within the research landscape since they provide essential infrastructures, experimental support and knowledge to…

The aim of this workshop was to give participants theoretical knowledge and practical insights into the factors that contribute to poor research…

Concluding the pilot implementation efforts initiated by the EQIPD consortium team, the Department of Behavioral Neuroscience and Drug Development at the Maj Institute…

EQIPD has developed a tool to support a) funders willing to communicate their expectations about data management and rigor in study…

As part of the PREMIER project, a document sharing system was developed and made freely available as a template to all interested parties…

The National Institute on Neurological Disorders and Stroke (NINDS) has been gathering a list of currently available public resources that are, or can…

 We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…

According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…

Science Forum: A community-led initiative for training in reproducible research Reproducibility: expect less of the scientific paper Share methods through visual…

Although the issues related to poor quality of medical research are well known, the research community fails to properly address them….

With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…

In registered reports (RRs), initial peer review and in-principle acceptance occur before knowing the research outcomes. This combats publication bias and…

Preclinical systematic reviews are vital; they serve many purposes by assessing the range and quality of the evidence. Through these reviews…

Together with the group of Ulf Kahlert from the University of Düsseldorf, PAASP’s Björn Gerlach published an article in F1000Research on…

Do I need to consider the sex of the animals for my study? Is the background noise level likely to vary?…

We have recently introduced the Materials, Design, Analysis, and Reporting (MDAR) framework aiming at helping authors, editors, and other interested parties to increase…

The UK Reproducibility Network (UKRN) has designed a new ‘primer series’ to introduce important topics in open and reproducible scholarship.Each primer…

On 25 August 2021, at the Virtual FENS Regional Meeting, Anton Bespalov and Malgorzata Pietraszek (PAASP) moderated the Special Interest Event…

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

Concluding the pilot implementation efforts initiated by the EQIPD consortium team, the first four Research Units have implemented the EQIPD Quality…

We have made substantial updates to the following EQIPD Toolbox items: 1.4.3.3 Academia-academia: Research as service: The recommendations outlined here are…

Besides this Newsletter, you will also find all relevant news and developments related to EQIPD on the eqipd.online website and in the EQIPD Toolbox….

NEWS  EQIPD news News on website – Read more Update on EQIPD Toolbox – Read more EQIPD-certified research units – Read more Workshop on…

Writing Standard Operating Procedures (SOP) is a usual procedure for any organization with a quality manage system. However, also an increasing…

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…

NEWS           – New EQIPD paper published – Read more          – The MDAR Framework –…

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…

Reproducibility of data has never been more at the forefront of scientific endeavour than now. In their latest contribution, the International…

On 21 April 2021 a virtual EQIPD workshop entitled “Rigor, reproducibility and data management in nonclinical research” was organized in Finland…

The Royal Society Open Science is promoting Registered Reports (RRs) by welcoming the submission of Stage 2 Registered Reports that have been…

The EQIPD Toolbox now contains a set of principles, which may help scientists, stakeholders and users to better understand what the…

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

NEWS from the PAASP network          – New series of EQIPD lectures – Read more         …

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

In 2018, the EU has launched the European Brain Research Area (EBRA) project – a catalysing platform designed to coordinate brain…

PAASP is a member of the science and industry cluster BioRN focusing on the Rhein-Neckar area. The cluster has a get-together with…

Sandrine Bongiovanni and Mathias Baumann (Novartis), Fiona Ducrey (Sanofi), Thomas Steckler and Anja Gilis (Janssen), Anton Bespalov (PAASP), Lee Monk (UCB),…

EQIPD has prepared and recorded a series of lectures introducing its novel Quality System. In these presentations, project coordinator Professor Malcolm Macleod provides…

Cohen Veterans Bioscience and ECNP announced on March 8th the “Negative Data Award 2021. Applicants are asked to submit a published…

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…