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Newsletter December 2020
December 18, 2020

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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A time to cast away stones, and a time to gather stones together
December 18, 2020

Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…

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ADDITIONAL READS IN DECEMBER 2020
December 18, 2020

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

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How often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

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Publication rate in preclinical research: a plea for preregistration
December 18, 2020

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

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Use of causal claims in observational studies: a research on research study
December 18, 2020

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

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Credibility of preprints: an interdisciplinary survey of researchers
December 18, 2020

Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…

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The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
December 18, 2020

Some causes for the problem of not being able to reproduce the work of others can be addressed when publishing scientific…

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The “replication crisis” in the public eye: Germans’ awareness and perceptions of the (ir)reproducibility of scientific research
December 18, 2020

While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…

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Great distinction for PAASP partner Martin C. Michel
December 18, 2020

Martin – once again – made it into the Clarivate List of Highly Cited Researchers 2020. This list recognizes true pioneers in…

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The BioRN annual conference
December 18, 2020

The BIOtech network Rhein-Neckar (BioRN) held its annual (digitally) conference virtually on November 20th. The network brings together a mix of…

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New publication co-authored by PAASP: Survey of Core Facilities shows the importance of communication and management for optimal research quality
December 18, 2020

PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…

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PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Successful adaption of the EQIPD Quality System to specific research needs
December 18, 2020

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Global Preclinical Data Forum, Cohen Veterans Bioscience and ECNP announced the Winner of the 2020 Best Negative Data Prize
October 8, 2020

The Global Preclinical Data Forum (GPDF), a jointly sponsored U.S. and European initiative, funded by Cohen Veterans Bioscience (CVB) and the…

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Newsletter October 2020
October 8, 2020

PAASP NEWS GPDF, CVB and ECNP announced the Winner of the 2020 Best Negative Data Prize – Read more Funding opportunities: Accelerating Publication…

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Violation of research integrity by selective citation
October 8, 2020

We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…

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Additional reads in October 2020
October 8, 2020

When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…

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How the COVID-19 pandemic highlights the necessity of animal research
October 8, 2020

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…

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Ten simple rules on how to write a standard operating procedure
October 8, 2020

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

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Reproducibility in systems biology modelling
October 8, 2020

The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…

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PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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EQIPD: PAASP’s contribution to the new Quality System for preclinical research
October 8, 2020

EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…

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PEERS – the Platform for the Exchange of Experimental Research Standards
October 8, 2020

We are happy to announce that PAASP is part of the PEERS (Platform for the Exchange of Experimental Research Standards) initiative, which is supported by…

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Funding opportunities: Accelerating Publication of Parkinson’s Disease Replication Data
October 8, 2020

To address the bias toward the publication of novel positive results, The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Reproducibility in systems biology modelling
August 25, 2020

A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…

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Signing digitally with Microsoft
August 17, 2020

A. Background & Definitions Microsoft Office (incl. Word, Excel and PowerPoint) offers the possibility to create a digital signature (digital ID) as…

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R script BestDose
August 17, 2020

library(scales)library(ggplot2) ## sample sizen1 <- 8n2 <- 16n3 <- 32n4 <- 64 ## iterations m <- 500yfig <- vector()xfig <- vector()facetfig…

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Risk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments
August 17, 2020

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Federal judge invalidates patents – but on the basis of a common statistical mistake
August 17, 2020

In a recent case before the US District Court in the District of Nevada, the judge ruled six method-of-use patents to…

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Our study was conducted according to…
August 17, 2020

Our stu Over the past several years, more and more journals have revised their guides for authors and included specific instructions…

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Additional reads in August 2020
August 17, 2020

Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…

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Choice of y-axis can mislead readers
August 17, 2020

Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…

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Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence
August 17, 2020

For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
August 17, 2020

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Academic criteria for promotion and tenure in biomedical sciences faculties: cross-sectional analysis of international sample of universities
August 17, 2020

Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…

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Reproducibility of animal research in light of biological variation
August 17, 2020

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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NIH Request for Information (RFI) aimed at enhancing rigor, transparency, and translatability to improve biomedical and behavioral research involving animal models
August 17, 2020

Since several months, there is a Working Group of the Advisory Committee to the NIH Director (ACD) that is charged with…

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Newsletter August 2020
August 17, 2020

NEWS          – PAASP US receives a Small Business Innovation Research (SBIR) grant – Read more         …

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Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Newsletter May 2020
May 28, 2020

NEWS The Global Preclinical Data Forum announces the 2020 Negative Data Prize – Read more Dr. Thomas Steckler joins the PAASP Advisory…

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Additional reads in May 2020
May 28, 2020

SuperPlots: Communicating reproducibility and variability in cell biology Against pandemic research exceptionalism Pseudoscience and COVID-19 — we’ve had enough already Spin…

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The Global Preclinical Data Forum announces the 2020 Negative Data Prize
May 28, 2020

The Global Preclinical Data Forum (GPDF), a partnership of Cohen Veterans Bioscience (CVB), a non-profit research biotech, and the European College…

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Octopus: The primary research record
May 28, 2020

Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…

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Using Microsoft OneNote as an ELN
May 28, 2020

Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…

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Beauty is not everything
May 28, 2020

Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…

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PLOS launches research data survey
May 28, 2020

PLOS has launched a major survey targeting researchers in North America and Europe: The goal is to deepen the understanding of…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
May 28, 2020

Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…

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Variability in the analysis of a single neuroimaging dataset by many teams
May 28, 2020

To test the reproducibility and robustness of results obtained in the neuroimaging field, 70 independent teams of neuroimaging experts from across…

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Covid-19 and the PPV
May 28, 2020

There has been a lot in the news recently about using antibody tests to detect people who have had Covid-19 and…

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Research rigor in preclinical studies on biological effects of whole-body exposure to electromagnetic fields (2G/3G cell phone technology)
May 26, 2020

Various modern technologies are known to bear risks to the human health. In many cases, the society learns about these risks…

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Conflict of interest – Education needed!
May 22, 2020

A “Conflict of Interest (CoI)” is a very special situation of which we are usually reminded about when a famous scientist…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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Sample Size Matters – An App Exploring Sample Size and Power
March 31, 2020

Problems with statistical analysis and data visualization in published papers (REF1, REF2, REF3, REF4) have led to calls to improve training for biomedical scientists….

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The Embassy of Good Science – An online platform fostering research integrity
March 31, 2020

By Iris Lechner The field of research integrity is growing substantially. An increasing number of guidelines and initiatives to foster responsible research…

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Data analysis – Issues, challenges and solutions
March 31, 2020

The first official meeting of the Preclinical Data Forum took place in Berlin in 2014 and one of the central seminars was given…

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Commentary March 2020
March 31, 2020

Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…

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Additional reads in March 2020
March 31, 2020

Preregistration of exploratory research: Learning from the golden age of discovery What Research Institutions Can Do to Foster Research Integrity When…

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Comparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature
March 31, 2020

Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to…

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Research Culture: Framework for advancing rigorous research
March 31, 2020

There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue,…

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Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative
March 31, 2020

The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…

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Research Culture and Reproducibility
March 31, 2020

There is an ongoing debate regarding the robustness and credibility of published scientific research. In this article, the authors argue that…

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No raw data, no science: another possible source of the reproducibility crisis
March 31, 2020

Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of irreproducibility….

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Improving quality of preclinical academic research through auditing: A feasibility study
March 31, 2020

Commentary provided by Claudia Kurreck (Department of Experimental Neurology, Charité -Universitätsmedizin Berlin, Germany) The performance of audits and assessments is always a…

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Coronavirus: The need for solid, robust data
March 31, 2020

Like everyone else we are with a great concern given the current coronavirus situation and the beginning of a global experiment:…

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Newsletter March 2020
March 31, 2020

Coronavirus: The need for solid, robust data – Read more Featured Publication: Improving quality of preclinical academic research through auditing: A feasibility study…

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Biological vs technical replicates: Now from a data analysis perspective: R script
March 31, 2020

This is the R Script referenced in the blog post LINK

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Biological vs technical replicates: Now from a data analysis perspective
March 31, 2020

We have discussed this topic several times before (HERE and HERE). There seems to be a growing understanding that, when reporting an experiment’s…

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Fun Section January 2020
February 1, 2020

A funny way to show the importance of describing your study/experiment in most detail and to be transparent and precise so…

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From fecal transplants, obesity and the importance of randomizatIon and normalization
February 1, 2020

In one of the last Newsletter issues (LINK), we wrote about the uncertainties which sometimes exist when trying to find the…

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Of lab notebooks and leaders in science
February 1, 2020

Good research practices are often said to work against the current success model in science (based on positive results, number and…

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Is N-Hacking ever OK?
February 1, 2020

It has been proposed repeatedly that adding samples based on results of initial experiments is a form of p-hacking (see e.g. new…

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Additional READS in January 2020
February 1, 2020

Measuring Transparency and Reproducibility of Biomedical Articles Causal claims about correlations reduced in press releases following academic study of health news…

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Is N-Hacking Ever OK? A simulation-based study
February 1, 2020

After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…

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Publishers’ Responsibilities in Promoting Data Quality and Reproducibility
February 1, 2020

Scholarly publishers can help to increase data quality and reproducible research by promoting transparency and openness. Increasing transparency can be achieved…

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Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods.
February 1, 2020

The reproducibility crisis in science is a multifaceted problem involving practices and incentives, both in the laboratory and in publication.Using SciScore,…

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New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
February 1, 2020

To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…

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Newsletter January 2020
February 1, 2020

News  NIH has awarded an SBIR grant to a PAASP Network member in the US – Read more New Author Guidelines to…

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PAASP US, LLC receives funding from NIH
January 29, 2020

The PAASP Network is very glad to announce that the NIH has awarded an SBIR grant to a Network member –…

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Most innovations are not advances: innovation + evaluation = progress
January 23, 2020

A blog post by Paul Glasziou from January 2013 starts with this headline, which is very much in line with our…

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Is N-Hacking Ever OK? A simulation-based study
January 2, 2020

After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…

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Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
December 18, 2019

Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.Design: Randomized controlled trial.Setting: Private or commercial…

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When p-hacking is not p-hacking – or: How shall the data be reported?
December 18, 2019

Organ bath experiments are a key technology to assess contractility of smooth muscle. When comparing force of contraction, investigators typically normalize…

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Instead of replicating studies with problems, let’s replicate the good studies
December 18, 2019

A few months ago, the “Reproducibility and Replicability in Science” report from the National Academies of Sciences, Engineering, and Medicine was…

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An ounce of prevention is worth a pound of cure
December 18, 2019

We have read with great interest a recent commentary in Nature about scientific research organizations hiring integrity reviewers to vet their manuscripts before…

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ADDITIONAL READS December 2019
December 18, 2019

Why scientists need to be better at data visualization Statistical significance gives bias a free pass Petitions in scientific argumentation: Dissecting…

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A consensus-based transparency checklist
December 18, 2019

Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…

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Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
December 18, 2019

Non-publication and publication bias in animal research are prominent topics in current debates on the “reproducibility crisis” and “failure rates in…

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PAASP at the REWARD/EQUATOR Conference in Berlin (February 20-22, 2020)
December 18, 2019

We will present our activities to improve Good Research Practice and Data Quality and are very much looking forward to meet…

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NIH Needs Your Feedback on a DRAFT NIH Policy for Data Management and Sharing
December 18, 2019

The draft policy requires all NIH-funded grantees to submit a Data Management and Sharing Plan outlining how researchers plan to manage scientific data,…

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March 3, 2020: Kick-Off Meeting – Quality Standards for In Vitro Research
December 18, 2019

Organized by the global Preclinical Data Forum, the meeting is aimed to start a discussion about developing specific quality guidelines and standards…

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