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Webinar at scientist.com
June 21, 2021

PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…

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Newsletter June 2021
June 16, 2021

NEWS           – New EQIPD paper published – Read more          – The MDAR Framework –…

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A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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How to See More Clearly in the Lab?
June 16, 2021

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

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Aducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

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Additional reads in June 2021
June 16, 2021

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

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Putting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

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Creating clear and informative image-based figures for scientific publications
June 16, 2021

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

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What is the optimum design for my animal experiment?
June 16, 2021

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

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Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research
June 16, 2021

The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…

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Standardized and reproducible measurement of decision-making in mice
June 16, 2021

Reproducibility of data has never been more at the forefront of scientific endeavour than now. In their latest contribution, the International…

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The EQIPD Workshop “Rigor, reproducibility and data management in nonclinical research”
June 16, 2021

On 21 April 2021 a virtual EQIPD workshop entitled “Rigor, reproducibility and data management in nonclinical research” was organized in Finland…

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Royal Society Open Science welcomes PCI Registered Reports
June 16, 2021

The Royal Society Open Science is promoting Registered Reports (RRs) by welcoming the submission of Stage 2 Registered Reports that have been…

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The EQIPD principles
June 16, 2021

The EQIPD Toolbox now contains a set of principles, which may help scientists, stakeholders and users to better understand what the…

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The MDAR Framework – a new tool for life sciences reporting
June 16, 2021

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

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EQIPD Quality System published
June 16, 2021

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

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Newsletter March 2021
March 30, 2021

NEWS from the PAASP network          – New series of EQIPD lectures – Read more         …

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A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

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WANTED – Cartoon artist
March 30, 2021

We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…

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Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

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Let’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021

by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…

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Additional reads in March 2021
March 30, 2021

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

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Reactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

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Taking a fresh look at FAIR for research software
March 30, 2021

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Reproducible image handling and analysis
March 30, 2021

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

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An excess of positive results: Comparing the standard Psychology literature with Registered Reports
March 30, 2021

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

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PREMOS – a new collaboration project involving EQIPD
March 30, 2021

In 2018, the EU has launched the European Brain Research Area (EBRA) project – a catalysing platform designed to coordinate brain…

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Presentation at the BioRN Lounge by Martin Michel
March 30, 2021

PAASP is a member of the science and industry cluster BioRN focusing on the Rhein-Neckar area. The cluster has a get-together with…

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EQIPD helps to define quality expectations for Industry-Academia collaborations
March 30, 2021

Sandrine Bongiovanni and Mathias Baumann (Novartis), Fiona Ducrey (Sanofi), Thomas Steckler and Anja Gilis (Janssen), Anton Bespalov (PAASP), Lee Monk (UCB),…

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New series of EQIPD lectures
March 30, 2021

EQIPD has prepared and recorded a series of lectures introducing its novel Quality System. In these presentations, project coordinator Professor Malcolm Macleod provides…

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Negative Data Award 2021
March 16, 2021

Cohen Veterans Bioscience and ECNP announced on March 8th the “Negative Data Award 2021. Applicants are asked to submit a published…

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Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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Newsletter December 2020
December 18, 2020

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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A time to cast away stones, and a time to gather stones together
December 18, 2020

Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…

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ADDITIONAL READS IN DECEMBER 2020
December 18, 2020

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

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How often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

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Publication rate in preclinical research: a plea for preregistration
December 18, 2020

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

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Use of causal claims in observational studies: a research on research study
December 18, 2020

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

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Credibility of preprints: an interdisciplinary survey of researchers
December 18, 2020

Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…

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The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
December 18, 2020

Some causes for the problem of not being able to reproduce the work of others can be addressed when publishing scientific…

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The “replication crisis” in the public eye: Germans’ awareness and perceptions of the (ir)reproducibility of scientific research
December 18, 2020

While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…

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Great distinction for PAASP partner Martin C. Michel
December 18, 2020

Martin – once again – made it into the Clarivate List of Highly Cited Researchers 2020. This list recognizes true pioneers in…

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The BioRN annual conference
December 18, 2020

The BIOtech network Rhein-Neckar (BioRN) held its annual (digitally) conference virtually on November 20th. The network brings together a mix of…

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New publication co-authored by PAASP: Survey of Core Facilities shows the importance of communication and management for optimal research quality
December 18, 2020

PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…

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PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Successful adaption of the EQIPD Quality System to specific research needs
December 18, 2020

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Global Preclinical Data Forum, Cohen Veterans Bioscience and ECNP announced the Winner of the 2020 Best Negative Data Prize
October 8, 2020

The Global Preclinical Data Forum (GPDF), a jointly sponsored U.S. and European initiative, funded by Cohen Veterans Bioscience (CVB) and the…

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Newsletter October 2020
October 8, 2020

PAASP NEWS GPDF, CVB and ECNP announced the Winner of the 2020 Best Negative Data Prize – Read more Funding opportunities: Accelerating Publication…

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Violation of research integrity by selective citation
October 8, 2020

We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…

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Additional reads in October 2020
October 8, 2020

When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…

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How the COVID-19 pandemic highlights the necessity of animal research
October 8, 2020

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…

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Ten simple rules on how to write a standard operating procedure
October 8, 2020

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

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Reproducibility in systems biology modelling
October 8, 2020

The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…

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PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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EQIPD: PAASP’s contribution to the new Quality System for preclinical research
October 8, 2020

EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…

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PEERS – the Platform for the Exchange of Experimental Research Standards
October 8, 2020

We are happy to announce that PAASP is part of the PEERS (Platform for the Exchange of Experimental Research Standards) initiative, which is supported by…

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Funding opportunities: Accelerating Publication of Parkinson’s Disease Replication Data
October 8, 2020

To address the bias toward the publication of novel positive results, The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Reproducibility in systems biology modelling
August 25, 2020

A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…

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Signing digitally with Microsoft
August 17, 2020

A. Background & Definitions Microsoft Office (incl. Word, Excel and PowerPoint) offers the possibility to create a digital signature (digital ID) as…

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R script BestDose
August 17, 2020

library(scales)library(ggplot2) ## sample sizen1 <- 8n2 <- 16n3 <- 32n4 <- 64 ## iterations m <- 500yfig <- vector()xfig <- vector()facetfig…

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Risk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments
August 17, 2020

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Federal judge invalidates patents – but on the basis of a common statistical mistake
August 17, 2020

In a recent case before the US District Court in the District of Nevada, the judge ruled six method-of-use patents to…

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Our study was conducted according to…
August 17, 2020

Our stu Over the past several years, more and more journals have revised their guides for authors and included specific instructions…

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Additional reads in August 2020
August 17, 2020

Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…

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Choice of y-axis can mislead readers
August 17, 2020

Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…

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Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence
August 17, 2020

For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
August 17, 2020

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Academic criteria for promotion and tenure in biomedical sciences faculties: cross-sectional analysis of international sample of universities
August 17, 2020

Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…

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Reproducibility of animal research in light of biological variation
August 17, 2020

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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NIH Request for Information (RFI) aimed at enhancing rigor, transparency, and translatability to improve biomedical and behavioral research involving animal models
August 17, 2020

Since several months, there is a Working Group of the Advisory Committee to the NIH Director (ACD) that is charged with…

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Newsletter August 2020
August 17, 2020

NEWS          – PAASP US receives a Small Business Innovation Research (SBIR) grant – Read more         …

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Scaling the y-axis
May 29, 2020

One of our colleagues sent us this interesting image from a national TV station. Even though the topic is very sad…

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Newsletter May 2020
May 28, 2020

NEWS The Global Preclinical Data Forum announces the 2020 Negative Data Prize – Read more Dr. Thomas Steckler joins the PAASP Advisory…

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Additional reads in May 2020
May 28, 2020

SuperPlots: Communicating reproducibility and variability in cell biology Against pandemic research exceptionalism Pseudoscience and COVID-19 — we’ve had enough already Spin…

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The Global Preclinical Data Forum announces the 2020 Negative Data Prize
May 28, 2020

The Global Preclinical Data Forum (GPDF), a partnership of Cohen Veterans Bioscience (CVB), a non-profit research biotech, and the European College…

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Octopus: The primary research record
May 28, 2020

Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…

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Using Microsoft OneNote as an ELN
May 28, 2020

Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…

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Beauty is not everything
May 28, 2020

Being able to trust the experimental data is critical for experimental research. This is certainly also true for Western Blotting as…

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PLOS launches research data survey
May 28, 2020

PLOS has launched a major survey targeting researchers in North America and Europe: The goal is to deepen the understanding of…

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Die Reproduzierbarkeitskrise: Bedrohung oder Chance für die Wissenschaft? (In German)
May 28, 2020

In this Editorial, published in Biologie in unserer Zeit, Martin C. Michel and Ralf Dahm discuss threats and opportunities related to…

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Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
May 28, 2020

Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…

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Variability in the analysis of a single neuroimaging dataset by many teams
May 28, 2020

To test the reproducibility and robustness of results obtained in the neuroimaging field, 70 independent teams of neuroimaging experts from across…

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Covid-19 and the PPV
May 28, 2020

There has been a lot in the news recently about using antibody tests to detect people who have had Covid-19 and…

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Research rigor in preclinical studies on biological effects of whole-body exposure to electromagnetic fields (2G/3G cell phone technology)
May 26, 2020

Various modern technologies are known to bear risks to the human health. In many cases, the society learns about these risks…

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Conflict of interest – Education needed!
May 22, 2020

A “Conflict of Interest (CoI)” is a very special situation of which we are usually reminded about when a famous scientist…

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Fun, fun, fun…
March 31, 2020

A mathematician, a physicist, and a statistician went hunting for deer. When they chanced upon one buck lounging about, the mathematician…

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Sample Size Matters – An App Exploring Sample Size and Power
March 31, 2020

Problems with statistical analysis and data visualization in published papers (REF1, REF2, REF3, REF4) have led to calls to improve training for biomedical scientists….

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The Embassy of Good Science – An online platform fostering research integrity
March 31, 2020

By Iris Lechner The field of research integrity is growing substantially. An increasing number of guidelines and initiatives to foster responsible research…

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Data analysis – Issues, challenges and solutions
March 31, 2020

The first official meeting of the Preclinical Data Forum took place in Berlin in 2014 and one of the central seminars was given…

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Commentary March 2020
March 31, 2020

Comment on Walsh et al. “The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility…

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Additional reads in March 2020
March 31, 2020

Preregistration of exploratory research: Learning from the golden age of discovery What Research Institutions Can Do to Foster Research Integrity When…

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