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November 3, 2021

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A wiki platform to support the organization of research labs
November 3, 2021

As part of the PREMIER project, a document sharing system was developed and made freely available as a template to all interested parties…

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NINDS Rigor Resources
November 3, 2021

The National Institute on Neurological Disorders and Stroke (NINDS) has been gathering a list of currently available public resources that are, or can…

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Of peer review and data sharing
November 3, 2021

 We (preclinical) learn from the Big Brother (clinical). For example, they recognize the risks of bias in study design, conduct and…

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“Don’t cut the tree you are sitting on!”
November 3, 2021

According to a recent press release from the European parliament, an EU-wide action plan is requested with ambitious and achievable objectives for phasing-out…

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Additional Reads in November 2021
November 3, 2021

Science Forum: A community-led initiative for training in reproducible research Reproducibility: expect less of the scientific paper Share methods through visual…

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Methodology over metrics: current scientific standards are a disservice to patients and society
November 3, 2021

Although the issues related to poor quality of medical research are well known, the research community fails to properly address them….

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Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021

With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…

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Initial evidence of research quality of registered reports compared with the standard publishing model
November 3, 2021

In registered reports (RRs), initial peer review and in-principle acceptance occur before knowing the research outcomes. This combats publication bias and…

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Technological advances in preclinical meta-research
November 3, 2021

Preclinical systematic reviews are vital; they serve many purposes by assessing the range and quality of the evidence. Through these reviews…

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eLabFTW as an Open Science tool to improve the quality and translation of preclinical research
November 3, 2021

Together with the group of Ulf Kahlert from the University of Düsseldorf, PAASP’s Björn Gerlach published an article in F1000Research on…

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PEERS – An Open Science “Platform for the Exchange of Experimental Research Standards” in Biomedicine
November 3, 2021

Do I need to consider the sex of the animals for my study? Is the background noise level likely to vary?…

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Materials Design Analysis Reporting (MDAR) Reports via SciScore
November 3, 2021

We have recently introduced the Materials, Design, Analysis, and Reporting (MDAR) framework aiming at helping authors, editors, and other interested parties to increase…

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UKRN: Open research primers
November 3, 2021

The UK Reproducibility Network (UKRN) has designed a new ‘primer series’ to introduce important topics in open and reproducible scholarship.Each primer…

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Meeting Report: Virtual FENS Regional Meeting 2021
November 3, 2021

On 25 August 2021, at the Virtual FENS Regional Meeting, Anton Bespalov and Malgorzata Pietraszek (PAASP) moderated the Special Interest Event…

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EATRIS Workshop on “Research Quality and Reproducibility”
November 3, 2021

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

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The first EQIPD-certified Research Units:
November 3, 2021

Concluding the pilot implementation efforts initiated by the EQIPD consortium team, the first four Research Units have implemented the EQIPD Quality…

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EQIPD Toolbox
November 3, 2021

We have made substantial updates to the following EQIPD Toolbox items: 1.4.3.3 Academia-academia: Research as service: The recommendations outlined here are…

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EQIPD News on webpage
November 3, 2021

Besides this Newsletter, you will also find all relevant news and developments related to EQIPD on the eqipd.online website and in the EQIPD Toolbox….

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Newsletter November 2021
November 3, 2021

NEWS  EQIPD news News on website – Read more Update on EQIPD Toolbox – Read more EQIPD-certified research units – Read more Workshop on…

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How to SOP
October 25, 2021

Writing Standard Operating Procedures (SOP) is a usual procedure for any organization with a quality manage system. However, also an increasing…

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ERIC forum reports on “Research Quality and Reproducibility Workshop”
October 21, 2021

European research infrastructures support academic research by providing networking opportunities and informing about current topics. In this context, the ERIC Forum…

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Webinar at scientist.com
June 21, 2021

PAASP network member Christoph Emmerich will introduce the EQIPD framework in the context of scientist.com. Scientist.com is a stakeholder of EQIPD…

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Newsletter June 2021
June 16, 2021

NEWS           – New EQIPD paper published – Read more          – The MDAR Framework –…

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A method to streamline p-hacking
June 16, 2021

The analytic strategy of p-hacking has rapidly accelerated the achievement of psychological scientists’ goals (e.g., publications & tenure), but has suffered…

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How to See More Clearly in the Lab?
June 16, 2021

When you can see the world clearly, it’s easy to get where you want to go: You might still get where…

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Aducanumab’s approval is not FDA’s failure, it is our failure
June 16, 2021

On June 7, 2021, the FDA approved aducanumab, an amyloid beta-directed monoclonal antibody indicated for the treatment of Alzheimer’s disease.However, most…

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Additional reads in June 2021
June 16, 2021

Nonreplicable publications are cited more than replicable ones Good research begins long before papers get written Why indirect contributions matter for…

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Putting the Self in Self-Correction: Findings from the Loss-of-Confidence Project
June 16, 2021

Science is often perceived to be a self-correcting enterprise. In principle, the assessment of scientific claims is supposed to proceed in…

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Creating clear and informative image-based figures for scientific publications
June 16, 2021

Scientists routinely use images to display data and images are a critical part of a scientific report or publication.However, many resources…

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What is the optimum design for my animal experiment?
June 16, 2021

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

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Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research
June 16, 2021

The long-held belief that experimental standardization begets replicability has recently been challenged – based on the observation that the reduction of…

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Standardized and reproducible measurement of decision-making in mice
June 16, 2021

Reproducibility of data has never been more at the forefront of scientific endeavour than now. In their latest contribution, the International…

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The EQIPD Workshop “Rigor, reproducibility and data management in nonclinical research”
June 16, 2021

On 21 April 2021 a virtual EQIPD workshop entitled “Rigor, reproducibility and data management in nonclinical research” was organized in Finland…

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Royal Society Open Science welcomes PCI Registered Reports
June 16, 2021

The Royal Society Open Science is promoting Registered Reports (RRs) by welcoming the submission of Stage 2 Registered Reports that have been…

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The EQIPD principles
June 16, 2021

The EQIPD Toolbox now contains a set of principles, which may help scientists, stakeholders and users to better understand what the…

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The MDAR Framework – a new tool for life sciences reporting
June 16, 2021

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

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EQIPD Quality System published
June 16, 2021

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

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Newsletter March 2021
March 30, 2021

NEWS from the PAASP network          – New series of EQIPD lectures – Read more         …

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A teaching tool about the fickle p-value and other statistical principles based on real-life data
March 30, 2021

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

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WANTED – Cartoon artist
March 30, 2021

We are all aware of the challenges modern science is facing. And we, like most readers of this newsletter, are working…

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Pseudoreplication in Physiology – more means less
March 30, 2021

Many publications leave it to readers to guess whether reported data are based on independent biological replicates (e.g. number of animals)…

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Let’s discuss reproducibility – the new “Journal for Reproducibility in Neuroscience”
March 30, 2021

by Plinio Cabrera Casarotto, PhD,Editor-in-Chief JRepNeurosci The replicability of results is a cornerstone of science. We can only rely on the outcomes…

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Additional reads in March 2021
March 30, 2021

Science Forum: Improving preclinical studies through replications Assessment of transparency indicators across the biomedical literature: How open is open? Von Botswana…

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Reactivation-dependent amnesia for contextual fear memories: Evidence for publication bias
March 30, 2021

Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in…

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Taking a fresh look at FAIR for research software
March 30, 2021

Software is increasingly essential in most research, and much of this software is developed specifically for and during research. To make this…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
March 30, 2021

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Reproducible image handling and analysis
March 30, 2021

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research…

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An excess of positive results: Comparing the standard Psychology literature with Registered Reports
March 30, 2021

Selectively publishing ‘positive’ results distorts the available evidence for scientific claims. For the past decade, scientists from different fields have been…

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PREMOS – a new collaboration project involving EQIPD
March 30, 2021

In 2018, the EU has launched the European Brain Research Area (EBRA) project – a catalysing platform designed to coordinate brain…

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Presentation at the BioRN Lounge by Martin Michel
March 30, 2021

PAASP is a member of the science and industry cluster BioRN focusing on the Rhein-Neckar area. The cluster has a get-together with…

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EQIPD helps to define quality expectations for Industry-Academia collaborations
March 30, 2021

Sandrine Bongiovanni and Mathias Baumann (Novartis), Fiona Ducrey (Sanofi), Thomas Steckler and Anja Gilis (Janssen), Anton Bespalov (PAASP), Lee Monk (UCB),…

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New series of EQIPD lectures
March 30, 2021

EQIPD has prepared and recorded a series of lectures introducing its novel Quality System. In these presentations, project coordinator Professor Malcolm Macleod provides…

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Negative Data Award 2021
March 16, 2021

Cohen Veterans Bioscience and ECNP announced on March 8th the “Negative Data Award 2021. Applicants are asked to submit a published…

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Careful interpretation of Western blotting data
February 23, 2021

Western blotting represents a powerful technique for the semi-quantitative determination of protein expression and the detection of protein modifications like phosphorylation…

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Newsletter December 2020
December 18, 2020

NEWS from the PAASP network Successful adaption of the EQIPD Quality System to specific research needs – Read more PAASP publication: Guidelines…

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How to organize data in a spreadsheet?
December 18, 2020

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

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Five rules for evidence communication
December 18, 2020

Communicating science is difficult. We were told to tell exciting stories around our scientific discoveries – and it is certainly true…

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The Costs of Competitiveness
December 18, 2020

In one of the recent Nature issues, there was a piece called “France’s reforms: the costs of competitiveness”. In a nutshell,…

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A time to cast away stones, and a time to gather stones together
December 18, 2020

Since the seminal paper by Laura Bohn 20 years ago, expectations have built up that biased mu-opioid receptor agonists will deliver what we…

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ADDITIONAL READS IN DECEMBER 2020
December 18, 2020

Collaboration on the road to better preclinical research Research integrity: nine ways to move from talk to walk Compliance Services for…

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How often do leading biomedical journals use statistical experts to evaluate statistical methods? The results of a survey
December 18, 2020

Scientific claims in biomedical research are typically derived from statistical analyses. However, misuse or misunderstanding of statistical procedures and results permeate…

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Publication rate in preclinical research: a plea for preregistration
December 18, 2020

In biomedical research, limitations in the design and reporting of experiments are known to cause avoidable waste of time and resources….

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Use of causal claims in observational studies: a research on research study
December 18, 2020

Many researchers remain tempted to draw causal conclusions from observational data despite acknowledging that mere association is not causation because causal…

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Credibility of preprints: an interdisciplinary survey of researchers
December 18, 2020

Preprints increase accessibility and can speed scholarly communication if researchers view them as credible enough to read and use. Preprint services…

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The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
December 18, 2020

Some causes for the problem of not being able to reproduce the work of others can be addressed when publishing scientific…

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The “replication crisis” in the public eye: Germans’ awareness and perceptions of the (ir)reproducibility of scientific research
December 18, 2020

While 90% of scientists surveyed by Nature feel that there is a “reproducibility crisis” in science (Baker, 2016), and major media…

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Great distinction for PAASP partner Martin C. Michel
December 18, 2020

Martin – once again – made it into the Clarivate List of Highly Cited Researchers 2020. This list recognizes true pioneers in…

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The BioRN annual conference
December 18, 2020

The BIOtech network Rhein-Neckar (BioRN) held its annual (digitally) conference virtually on November 20th. The network brings together a mix of…

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New publication co-authored by PAASP: Survey of Core Facilities shows the importance of communication and management for optimal research quality
December 18, 2020

PAASP and the Interdisciplinary Neurobehavioral Core (INBC) at the University of Heidelberg aim to establish a quality framework for Core Facilities…

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PAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020

The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…

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Successful adaption of the EQIPD Quality System to specific research needs
December 18, 2020

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

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Guidelines for target validation published
November 16, 2020

The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…

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The Global Preclinical Data Forum, Cohen Veterans Bioscience and ECNP announced the Winner of the 2020 Best Negative Data Prize
October 8, 2020

The Global Preclinical Data Forum (GPDF), a jointly sponsored U.S. and European initiative, funded by Cohen Veterans Bioscience (CVB) and the…

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Newsletter October 2020
October 8, 2020

PAASP NEWS GPDF, CVB and ECNP announced the Winner of the 2020 Best Negative Data Prize – Read more Funding opportunities: Accelerating Publication…

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Violation of research integrity by selective citation
October 8, 2020

We have written repeatedly (LINK, LINK) about the border between the fields of Good Research Practice and Research Integrity being more nuanced…

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Additional reads in October 2020
October 8, 2020

When antibodies mislead: the quest for validation Von Maus zu Mensch durch das Tal des Todes (in German) Researchers’ Perceptions of…

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How the COVID-19 pandemic highlights the necessity of animal research
October 8, 2020

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium…

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Ten simple rules on how to write a standard operating procedure
October 8, 2020

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

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Reproducibility in systems biology modelling
October 8, 2020

The reproducibility crisis has emerged as an important concern across many fields of science. Systems biology modelling, which involves mathematical representation…

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PAASP Editorial in the Journal Temperature
October 8, 2020

Please following this LINK to our Editorial “Enhancing quality in preclinical data: Of hot science and cool quality”, which was just published in…

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EQIPD: PAASP’s contribution to the new Quality System for preclinical research
October 8, 2020

EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…

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PEERS – the Platform for the Exchange of Experimental Research Standards
October 8, 2020

We are happy to announce that PAASP is part of the PEERS (Platform for the Exchange of Experimental Research Standards) initiative, which is supported by…

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Funding opportunities: Accelerating Publication of Parkinson’s Disease Replication Data
October 8, 2020

To address the bias toward the publication of novel positive results, The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and…

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In vivo veritas
October 5, 2020

Most of our readers are biologists but nevertheless we are occasionally exposed to medicinal chemistry literature describing novel research tools, lead…

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Reproducibility in systems biology modelling
August 25, 2020

A recent report by Tiwari et al. investigated the reproducibility rate in systems biology modelling by reproducing the mathematical representation of 455 kinetic…

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Signing digitally with Microsoft
August 17, 2020

A. Background & Definitions Microsoft Office (incl. Word, Excel and PowerPoint) offers the possibility to create a digital signature (digital ID) as…

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R script BestDose
August 17, 2020

library(scales)library(ggplot2) ## sample sizen1 <- 8n2 <- 16n3 <- 32n4 <- 64 ## iterations m <- 500yfig <- vector()xfig <- vector()facetfig…

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Risk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments
August 17, 2020

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

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Best-dose analysis – A confirmatory research case
August 17, 2020

It is often observed and discussed that there are substantial inter-individual differences that can overshadow effects of otherwise effective treatments.  These…

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Federal judge invalidates patents – but on the basis of a common statistical mistake
August 17, 2020

In a recent case before the US District Court in the District of Nevada, the judge ruled six method-of-use patents to…

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Our study was conducted according to…
August 17, 2020

Our stu Over the past several years, more and more journals have revised their guides for authors and included specific instructions…

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Additional reads in August 2020
August 17, 2020

Five better ways to assess science $48 Billion Is Lost to Avoidable Experiment Expenditure Every Year Opinion: Surgisphere Fiasco Highlights Need…

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Choice of y-axis can mislead readers
August 17, 2020

Biases at the level of study design, conduct, data analysis and reporting have been recognized as major contributing factors to poor…

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Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence
August 17, 2020

For neuroscience and brain research to progress, it is critical to differentiate between experimental manipulations which have no effect and those…

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Advancing science or advancing careers? Researchers’ opinions on success indicators
August 17, 2020

The way in which we assess researchers has been under the radar in the past few years. Critics argue that current…

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Academic criteria for promotion and tenure in biomedical sciences faculties: cross-sectional analysis of international sample of universities
August 17, 2020

Understanding the variability of criteria and thresholds for promotion and tenure applied across institutions requires a systematic empirical assessment. Therefore, the…

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Reproducibility of animal research in light of biological variation
August 17, 2020

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental…

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The Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020

For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…

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Impact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020

Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…

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