In animal experiments, blinding is a methodological strategy to reduce the risk that scientists, animal care staff, or other staff involved…

Meta-analytic techniques have been widely used to synthesize data from animal models of human diseases and conditions, but these analyses often…

In this review, Emma Wilson and colleagues aim to engage researchers in the discussion on research reproducibility and to provide the…

We are thrilled to announce that we have completed the development of our Good Research Practice online course and it will…

In many fields of biomedical research, in vivo studies traditionally involved the use of male subjects.  The situation recently started to…

This is the script which is mentioned in the article HERE.

Destroying image integrity in scientific papers may result in serious consequences. Inappropriate duplication and fabrication of images are two common misconducts…

Immortalized or continuous cell lines are invaluable tools in basic and preclinical research. However, the widespread use of misidentified cell lines…

This tool was originally developed by an EQIPD Consortium Taskforce and is now implemented online with support from a SBIR award…

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image…

Although commonly acknowledged and applied in clinical research since 2000, preregistration of animal studies is not yet the norm. In 2018…

This is the R Script referenced in the blog post LINK # ratio of true to not-true relationships tnott

In this wiki, the author provides an easy to navigate list of references that may be used to argue against some common…

As part of the PREMIER project, a document sharing system was developed and made freely available as a template to all interested parties…

The National Institute on Neurological Disorders and Stroke (NINDS) has been gathering a list of currently available public resources that are, or can…

We have recently introduced the Materials, Design, Analysis, and Reporting (MDAR) framework aiming at helping authors, editors, and other interested parties to increase…

Writing Standard Operating Procedures (SOP) is a usual procedure for any organization with a quality manage system. However, also an increasing…

Within preclinical research, attention has focused on experimental design and how current practices can lead to poor reproducibility. There are numerous…

Incomplete or imprecise reporting of life sciences research contributes to challenges with reproducibility, replicability, and biomedical applications. For the last three…

The manuscript “Introduction to the EQIPD quality system” was recently accepted by and published in eLife. This publication marks an important milestone…

A poor understanding of what results from statistical tests do and do not mean and an over-reliance on p-values is seen…

Sandrine Bongiovanni and Mathias Baumann (Novartis), Fiona Ducrey (Sanofi), Thomas Steckler and Anja Gilis (Janssen), Anton Bespalov (PAASP), Lee Monk (UCB),…

Spreadsheets are widely used as a digital tool to capture, organize, process and archive information. However, to organize the information provided…

The EQIPD Quality System is the result of a collaborative effort between several people and organizations, yet it cannot address all…

The long-term accessibility of research data is fundamental in the economy of the research production process. However, the availability of data…

EQIPD (European Quality In Preclinical Data) is a project that was funded by the Innovative Medicine Initiative with the vision to enable a…

A. Background & Definitions Microsoft Office (incl. Word, Excel and PowerPoint) offers the possibility to create a digital signature (digital ID) as…

library(scales)library(ggplot2) ## sample sizen1 <- 8n2 <- 16n3 <- 32n4 <- 64 ## iterations m <- 500yfig <- vector()xfig <- vector()facetfig…

There is currently no generic tool for producing figures to display and explore the risk‐of‐bias assessments that routinely take place as…

Created in partnership with the UK Reproducibility Network, the Octopus platform is free to use and publishes all kinds of scientific…

Electronic research data documentation can be achieved with either comprehensive software applications or “do-it-yourself” solutions. Whereas the first is often quite…

Problems with statistical analysis and data visualization in published papers (REF1, REF2, REF3, REF4) have led to calls to improve training for biomedical scientists….

By Iris Lechner The field of research integrity is growing substantially. An increasing number of guidelines and initiatives to foster responsible research…

This is the R Script referenced in the blog post LINK ## “Effortlessly Read Any Rectangular Data”library(readit)         …

We have discussed this topic several times before (HERE and HERE). There seems to be a growing understanding that, when reporting an experiment’s…

After an experiment has been completed and analyzed, a trend may be observed that is “not quite significant”. Sometimes in this…

By Dr. Michael Lauer (NIH) Link to web page

Many areas of biomedical science have developed reporting standards and checklists to support the adequate reporting of scientific efforts, but in…

The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and…

fiddle is a free, open source “matchmaking” tool designed to help researchers to identify the publication format that will work best for…

A series of videos is published about EQIPD by the ECNP network. The first video gives a brief introduction by Dr…

LabsExplorer has recently published an updated review on electronic lab notebooks. The first review was published in 2017 (LINK) giving a…

Teemu D. Laajala1,21: University of Turku, Turku (Finland), Department of Mathematics and Statistics2: University of Colorado, Denver (CO, US), Anschutz Medical…

We say we need standards, but do we use them?The scientific community, funders and publishers endorse the concept that common data…

In within-subject study designs (also known as the cross-over), subjects may be given sequences of treatments with the intent of studying…

In this article,Weissgerber et al. present findings suggesting that scientific publications are often lacking sufficient information about the statistical methods used,…

The rapid increase in volume and complexity of biomedical data requires changes in research, communication, and clinical practices. This includes learning…

ERA-NET Neuron organised a workshop research data quality on January 22nd, 2019 in Bonn. PAASP Team members, Anton Bespalov and Martin…

In the recent report on „Digital tools and services to support research replicability and verifiability”, Caroline Skirrow and Markus Munafó have argued that…

Digital tools hold promise for improving replicability and verifiability of scientific research. In this paper, the availability and use of such…

The example below does not require any additional R packages to be installed (i.e. runs with the basic R installation).This example…

A new video resource for introductory training on the 3Rs The NC3R published a new educational video on the 3Rs (replacement,…

Today, the probability of successfully publishing negative/null results in biomedical research is lower than that for positive results. For instance, negative…

The NC3R published a new educational video on the 3Rs (replacement, refinement and replacement) on their web page. It is a…

On May 9th, 2018, a workshop hosted by the NC3Rs about „Improving peer review of in vivo research proposals“ and included…

Commentary about the Nature-Toolbox article by Roberta Kwok (August 6th, 2018) Laboratory Notebooks (LN) play a key role in research since…

In this paper, published in Nature, the authors analysed how different cancer cells are – not so much from the original…

Lenny Teytelman wrote in a Nature – World View article about the necessity to share experimental protocols to be able to…

Unambiguous identification of antibodies, cell lines and organisms around the globe: A call for the Research Resource ID The reproducibility crisis…

Data recording practices play a central element in research and can vary largely from lab to lab and researcher to researcher….

In this clearly and graphically explained educational video, Amber Biology offers an intuitive introduction to Bayes’ Theorem, using biomarkers and ovarian cancer…

Underpowered experiments have three problems: true effects are harder to detect, the true effects that are detected tend to have inflated…

Recommendations for the Design and Analysis of In Vivo Electrophysiology Studies The Journal of Neuroscience has recently released a series of…

The International Council for Laboratory Animal Science (ICLAS) has recently published Harmonized Animal Research Reporting Principles (HARRP), the first step of…

On 2018 July 25th, the SpringerProtocols.com platform will be deactivated and replaced by the new research platform Springer Nature Experiments, a…

A healthy research environment is fundamental to good science. However, this is an aspect that is rarely discussed. That’s partly because…

“Accurate Design of in vitro experiments – Why does it matter?” was the name of a previous post (LINK) from our…

This episode is part of Healthcare Triage’s series on Improving Reproducibility in Research. The Introduction to the series can be found…

The Food and Drug Administration Act of 2007 established requirements for the preregistration of clinical trials and also set penalties for…

In this article, Nancy Baker and colleagues introduce the Abstract Sifter, a Microsoft Excel based application that enhances existing search capabilities…

This website was published by Tom MacWright and contributers to provide a library of statistical methods in readible JavaScript. This detailed…

PAASP, Henrich Pharma Consulting and Global Clinical Trials (GCT) are the founding members of the Pharma Innovation Excellence (PHINNEX) consortium What…

Addressing the common problems that researchers encounter when designing and analyzing animal experiments will improve the reliability of in vivo research….

A randomization tool for the daily routine The case study in this Newsletter illustrates very well the importance of study subject…

In this section we provide information about useful tools for designing and analyzing experiments – instruments and equipment, which we at…

In this Newsletter issue, we introduce helpful resources for educational and training purposes, which were recently published and which all address…

In this Newsletter issue, we introduce helpful resources for educational and training purposes, which were recently published and which all address…

Prof. Dr. Martin Michel presented the November Cohen Veterans Bioscience Webinar on November 16th from 12 pm noon – 1 pm ET. Martin…

Good statistical design is a key aspect of meaningful research. Elements such as data robustness, randomization and blinding are widely recognized…

To examine associations between urinary chemical concentrations and adult health status, the US Centers for Disease Control and Prevention (CDC) measured…

There are a variety of free online tools that can be easily accessed to address various data analysis needs, such as…

E-learning platforms and Massive Open Online Courses (MOOCs) are picking up momentum in popularity and are an emerging new model for…

E-learning platforms and Massive Open Online Courses (MOOCs) are picking up momentum in popularity and are an emerging new model for…